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Cct7 Gene Detail
Summary
  • Symbol
    Cct7
  • Name
    chaperonin containing TCP1 subunit 7
  • Synonyms
    Ccth, Cctz
  • Feature Type
    protein coding gene
  • IDs
    MGI:107184
    NCBI Gene: 12468
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85428496-85445457 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.46 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    351 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107184
 protein coding gene Chr6:85428487-85445459 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030955
 protein coding gene Chr6:86618138-86636294 (+)
A/J MGP_AJ_G0030924
 protein coding gene Chr6:83320322-83338513 (+)
AKR/J MGP_AKRJ_G0030852
 protein coding gene Chr6:85733523-85752705 (+)
BALB/cJ MGP_BALBcJ_G0030934
 protein coding gene Chr6:83312814-83329775 (+)
C3H/HeJ MGP_C3HHeJ_G0030776
 protein coding gene Chr6:98695232-98712193 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031394
 protein coding gene Chr6:89002608-89019569 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028579
 protein coding gene Chr6:81593825-81609605 (+)
CAST/EiJ MGP_CASTEiJ_G0030043
 protein coding gene Chr6:85748302-85765263 (+)
CBA/J MGP_CBAJ_G0030621
 protein coding gene Chr6:92491712-92508673 (+)
DBA/2J MGP_DBA2J_G0030774
 protein coding gene Chr6:82603379-82620340 (+)
FVB/NJ MGP_FVBNJ_G0030727
 protein coding gene Chr6:81805519-81822479 (+)
LP/J MGP_LPJ_G0030853
 protein coding gene Chr6:86613912-86630873 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030763
 protein coding gene Chr6:96696385-96713345 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031418
 protein coding gene Chr6:85534232-85552464 (+)
PWK/PhJ MGP_PWKPhJ_G0029758
 protein coding gene Chr6:81538620-81555610 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029586
 protein coding gene Chr6:84392309-84409242 (+)
WSB/EiJ MGP_WSBEiJ_G0030124
 protein coding gene Chr6:85983006-86001903 (+)



Homology
more
  • Human Ortholog
    CCT7, chaperonin containing TCP1 subunit 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCT7, chaperonin containing TCP1 subunit 7
  • Synonyms
    CCTETA, CCTH, NIP7-1, TCP1ETA
  • Links
    NCBI Gene ID: 10574
    neXtProt AC: NX_Q99832
    UniProt: Q99832

  • Chr Location
    2p13.2; chr2:73233420-73253021 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030007 Ensembl Gene Model | MGI Sequence Detail 16962 C57BL/6J ±  kb
transcript ENSMUST00000032078 Ensembl | MGI Sequence Detail 2441 Not Applicable  
polypeptide ENSMUSP00000032078 Ensembl | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000005156 T-complex protein 1 subunit eta
    (term hierarchy)
  • InterPro Domains
    IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
    IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain superfamily
    IPR027413 GroEL-like equatorial domain superfamily
    IPR012720 T-complex protein 1, eta subunit
    IPR053374 TCP-1 chaperonin-containing T-complex
    IPR027410 TCP-1-like chaperonin intermediate domain superfamily
  • GlyGen
    P80313 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35645, MGI:2141360, MGI:2141529
References
more
  • Summaries
    All 51
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:18119 O'Bryan JP, et al., axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory