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Cct2 Gene Detail
Summary
  • Symbol
    Cct2
  • Name
    chaperonin containing TCP1 subunit 2
  • Synonyms
    Cctb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107186
    NCBI Gene: 12461
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116886906-116899719 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 65.07 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107186
 protein coding gene Chr10:116886902-116899757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017752
 protein coding gene Chr10:119872437-119885247 (-)
A/J MGP_AJ_G0017728
 protein coding gene Chr10:115246891-115259707 (-)
AKR/J MGP_AKRJ_G0017690
 protein coding gene Chr10:118595836-118608544 (-)
BALB/cJ MGP_BALBcJ_G0017691
 protein coding gene Chr10:115647973-115660789 (-)
C3H/HeJ MGP_C3HHeJ_G0017516
 protein coding gene Chr10:118819676-118832532 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018148
 protein coding gene Chr10:124034592-124047408 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015827
 protein coding gene Chr10:109837914-109851752 (-)
CAST/EiJ MGP_CASTEiJ_G0017078
 protein coding gene Chr10:119133796-119147007 (-)
CBA/J MGP_CBAJ_G0017485
 protein coding gene Chr10:128917640-128930470 (-)
DBA/2J MGP_DBA2J_G0017590
 protein coding gene Chr10:114386668-114399484 (-)
FVB/NJ MGP_FVBNJ_G0017585
 protein coding gene Chr10:113337192-113350008 (-)
LP/J MGP_LPJ_G0017665
 protein coding gene Chr10:120461111-120473941 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017614
 protein coding gene Chr10:131780570-131793386 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018186
 protein coding gene Chr10:118665035-118677851 (-)
PWK/PhJ MGP_PWKPhJ_G0016860
 protein coding gene Chr10:114485439-114499218 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016650
 protein coding gene Chr10:117475533-117488207 (-)
WSB/EiJ MGP_WSBEiJ_G0017138
 protein coding gene Chr10:118866720-118879595 (-)



Homology
more
  • Human Ortholog
    CCT2, chaperonin containing TCP1 subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCT2, chaperonin containing TCP1 subunit 2
  • Synonyms
    99D8.1, CCTB, CCT-beta, HEL-S-100n, PRO1633, TCP-1-beta
  • Links
    NCBI Gene ID: 10576
    neXtProt AC: NX_P78371
    UniProt: P78371

  • Chr Location
    12q15; chr12:69585426-69601570 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cct2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    11
  • cDNA Data
    643
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034024 Ensembl Gene Model | MGI Sequence Detail 12814 C57BL/6J ±  kb
    transcript ENSMUST00000047672 Ensembl | MGI Sequence Detail 1959 Not Applicable  
    polypeptide ENSMUSP00000036288 Ensembl | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000005150 T-complex protein 1 subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
      IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
      IPR002194 Chaperonin TCP-1, conserved site
      IPR027409 GroEL-like apical domain superfamily
      IPR027413 GroEL-like equatorial domain superfamily
      IPR012716 T-complex protein 1, beta subunit
      IPR053374 TCP-1 chaperonin-containing T-complex
      IPR027410 TCP-1-like chaperonin intermediate domain superfamily
    • GlyGen
      P80314 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 646
      cDNA 643
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35647
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:358007 Suga A, et al., Compound heterozygous mutations in a mouse model of Leber congenital amaurosis reveal the role of CCT2 in photoreceptor maintenance. Commun Biol. 2024 Jun 3;7(1):676
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory