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Bmpr1b
Gene Detail
Symbol

Name
ID
Bmpr1b
bone morphogenetic protein receptor, type 1B
MGI:107191
Synonyms
Acvrlk6, Alk6, BMPR-IB, CFK-43a
Feature Type
protein coding gene
Genetic Map
Chromosome 3
66.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:141837136-142169425 bp, - strand
From VEGA annotation of GRCm38

  332290 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20322  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BMPR1B
Protein SuperFamily: type I serine/threonine-protein kinase receptor, Activin/BMP/TGF-beta types
Gene Tree: Bmpr1b

Human
homologs
BMPR1B, bone morphogenetic protein receptor, type IB
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 658
neXtProt AC: NX_O00238

Human Synonyms: ALK6, ALK-6, CDw293

Human Chr (Location): 4q22-q24; chr4:94757977-95158450 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human BMPR1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(1) Transgenic(1) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutantions of this gene affect the shape of the distal limb skeleton resulting in brachydactyly or failure to generate digit cartilage. Furthermore, inactivation results in female sterility due to abnormal oestrus cyclicity as well as retinal abnormalities.
 
Phenotype Images(4)
Interactions
Bmpr1b interacts with 370 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process BMP signaling pathway, camera-type eye development, ...
Component integral component of membrane, membrane
Function ATP binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (77 records)
Data Summary: Results (456)    Tissues (250)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 344
Northern blot 8
Western blot 25
RT-PCR 74
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA BMPR1B ; Xenbase bmpr1b ; ZFIN bmpr1ba, bmpr1bb    NEW 
Molecular
reagents
All nucleic(57) cDNA(46) Primer pair(8) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000025350 (Evidence)
Ensembl Gene Model ENSMUSG00000052430 (Evidence)
Entrez Gene 12167 (Evidence)
UniGene 39089
DFCI TC1582865, TC1609027, TC1624588
DoTS DT.40140320, DT.101367792, DT.111061126, DT.101141340, DT.101135002
NIA Mouse Gene Index U024712
EC 2.7.11.30
PDB 3EVS
Consensus CDS Project CCDS17874.1
International Mouse Phenotyping Consortium Status Bmpr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025350 VEGA Gene Model | MGI Sequence Detail 332290 C57BL/6J ±  kb
transcript OTTMUST00000062401 VEGA | MGI Sequence Detail 4164 Not Applicable 
polypeptide OTTMUSP00000030751 VEGA | MGI Sequence Detail 502 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(26) UniProt(4)
Polymorphisms
SNPs within 2kb(4260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
InterPro IPR003605 TGF beta receptor, GS motif
Protein Ontology PR:000000036 BMP receptor type-1B
References
(Earliest) J:22224 Yamaji N, et al., A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun. 1994 Dec 30;205(3):1944-51
(Latest) J:214844 Andree M, et al., BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2014 Jul 23;
All references(183)
Other
accession IDs
MGD-MRK-35652, MGI:2139685, MGI:2139946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory