Adam7 MGI Mouse Gene Detail - MGI:107247 - a disintegrin and metallopeptidase domain 7

Symbol

Adam7
Name

a disintegrin and metallopeptidase domain 7
Synonyms

EAP1

Feature Type

protein coding gene
IDs

MGI:107247
NCBI Gene: 11500
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:68734785-68771138 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 35.69 cM
Mapping Data

3 experiments

SNPs within 2kb

1487 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107247	protein coding gene	Chr14:68734785-68771190 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021510	protein coding gene	Chr14:63272227-63309962 (-)
A/J	MGP_AJ_G0021469	protein coding gene	Chr14:61749712-61785932 (-)
AKR/J	MGP_AKRJ_G0021445	protein coding gene	Chr14:63836252-63872028 (-)
BALB/cJ	MGP_BALBcJ_G0021475	protein coding gene	Chr14:61733815-61774049 (-)
C3H/HeJ	MGP_C3HHeJ_G0021252	protein coding gene	Chr14:63581497-63619425 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021914	protein coding gene	Chr14:66132043-66173642 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019454	protein coding gene	Chr14:59633452-59670603 (-)
CAST/EiJ	MGP_CASTEiJ_G0020769	protein coding gene	Chr14:60088029-60129185 (-)
CBA/J	MGP_CBAJ_G0021219	protein coding gene	Chr14:68159362-68197474 (-)
DBA/2J	MGP_DBA2J_G0021342	protein coding gene	Chr14:61363573-61403592 (-)
FVB/NJ	MGP_FVBNJ_G0021321	protein coding gene	Chr14:60772420-60807916 (-)
LP/J	MGP_LPJ_G0021417	protein coding gene	Chr14:64328217-64370593 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021350	protein coding gene	Chr14:67122957-67164270 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021937	protein coding gene	Chr14:63075482-63117620 (-)
PWK/PhJ	MGP_PWKPhJ_G0020513	protein coding gene	Chr14:58129971-58166925 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020346	protein coding gene	Chr14:59012289-59050844 (-)
WSB/EiJ	MGP_WSBEiJ_G0020822	protein coding gene	Chr14:63397767-63435021 (-)

Human Ortholog

ADAM7, ADAM metallopeptidase domain 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAM7, ADAM metallopeptidase domain 7
Synonyms

ADAM 7, ADAM-7, EAPI, GP-83, GP83
Links

HGNC:214

NCBI Gene ID: 8756

neXtProt AC: NX_Q9H2U9

UniProt: Q9H2U9
Chr Location

8p21.2; chr8:24440930-24526970 (+) GRCh38

MGI Vertebrate Homology

Adam7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADAM7
Gene Tree

Adam7

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

3
Genomic Mutations

1 involving Adam7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced male fertility with decreased cell height in caput epididymis, spermatic granuloma, kinked sperm flagellum and reduced sperm motility.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

4
CCDS

CCDS27234.1

Ensembl

ENSMUSG00000022056 (Evidence)
NCBI Gene

11500

			Length	Strain/Species	Flank
genomic	11500	NCBI Gene Model \| MGI Sequence Detail	36354	C57BL/6J	± kb
transcript	NM_007402	RefSeq \| MGI Sequence Detail	3469	C57BL/6
polypeptide	O35227	UniProt \| EBI \| MGI Sequence Detail	789	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003724 disintegrin and metalloproteinase domain-containing protein 7

(term hierarchy)
InterPro Domains

IPR006586 ADAM, cysteine-rich domain

IPR018358 Disintegrin, conserved site

IPR001762 Disintegrin domain

IPR036436 Disintegrin domain superfamily

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR001590 Peptidase M12B, ADAM/reprolysin

IPR002870 Peptidase M12B, propeptide

IPR034027 Reprolysin domain, adamalysin-type
GlyGen

O35227 6 sites

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All nucleic 7

Genomic 2

cDNA 5

Microarray probesets 3

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MGD-MRK-35712

Summaries

All 37

Gene Ontology 8

Phenotypes 10
Earliest

J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
Latest

J:226260 Choi H, et al., Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Biol Reprod. 2015 Sep;93(3):70

TSS for Adam7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129430	Chr14:68771271-68771274 (-)	-135 bp
Tssr4466	Chr14:68771256-68771263 (-)	-122 bp
Tssr129429	Chr14:68771232-68771243 (-)	-100 bp
Tssr129428	Chr14:68771211-68771230 (-)	-83 bp
Tssr129427	Chr14:68771180-68771206 (-)	-55 bp
Tssr129426	Chr14:68762701-68762711 (-)	8,432 bp
Tssr129425	Chr14:68742081-68742088 (-)	29,053 bp
Tssr129424	Chr14:68735467-68735499 (-)	35,655 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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