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Fyco1 Gene Detail
Summary
  • Symbol
    Fyco1
  • Name
    FYVE and coiled-coil domain containing 1
  • Synonyms
    2810409M01Rik, Mem2, ZFYVE7
  • Feature Type
    protein coding gene
  • IDs
    MGI:107277
    NCBI Gene: 17281
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123618565-123680964 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 74.52 cM, cytoband F
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1780 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107277
 protein coding gene Chr9:123618565-123681110 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035483
 protein coding gene Chr9:126840346-126903814 (-)
A/J MGP_AJ_G0035464
 protein coding gene Chr9:121996220-122059065 (-)
AKR/J MGP_AKRJ_G0035397
 protein coding gene Chr9:125261928-125324288 (-)
BALB/cJ MGP_BALBcJ_G0035460
 protein coding gene Chr9:121925530-121988006 (-)
C3H/HeJ MGP_C3HHeJ_G0035167
 protein coding gene Chr9:125708287-125773244 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035983
 protein coding gene Chr9:130348826-130413202 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032865
 protein coding gene Chr9:119097023-119165918 (-)
CAST/EiJ MGP_CASTEiJ_G0034472
 protein coding gene Chr9:125756286-125825417 (-)
CBA/J MGP_CBAJ_G0035135
 protein coding gene Chr9:135113355-135177445 (-)
DBA/2J MGP_DBA2J_G0035294
 protein coding gene Chr9:121436483-121499514 (-)
FVB/NJ MGP_FVBNJ_G0035241
 protein coding gene Chr9:120341156-120403216 (-)
LP/J MGP_LPJ_G0035373
 protein coding gene Chr9:127242177-127308457 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035282
 protein coding gene Chr9:135923447-135987969 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036002
 protein coding gene Chr9:125728141-125793729 (-)
PWK/PhJ MGP_PWKPhJ_G0034176
 protein coding gene Chr9:121895107-121959093 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034013
 protein coding gene Chr9:125832262-125895097 (-)
WSB/EiJ MGP_WSBEiJ_G0034592
 protein coding gene Chr9:125561492-125626212 (-)



Homology
more
  • Human Ortholog
    FYCO1, FYVE and coiled-coil domain autophagy adaptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FYCO1, FYVE and coiled-coil domain autophagy adaptor 1
  • Synonyms
    CATC2, CTRCT18, RUFY3, ZFYVE7
  • Links
    NCBI Gene ID: 79443
    neXtProt AC: NX_Q9BQS8
    UniProt: Q9BQS8

  • Chr Location
    3p21.31; chr3:45917903-45995824 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FYCO1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations of this gene result in reduced autophagic flux, abnormal retention of cellular organelles during lens fiber cell differentiation, and bilateral cataract formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    28
  • cDNA Data
    68
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025241 Ensembl Gene Model | MGI Sequence Detail 62400 C57BL/6J ±  kb
    transcript ENSMUST00000084715 Ensembl | MGI Sequence Detail 7949 Not Applicable  
    polypeptide ENSMUSP00000081764 Ensembl | MGI Sequence Detail 1437 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 70
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35742, MGI:1917454
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:40042 Heyer BS, et al., New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997 Jun;47(2):148-56
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory