About   Help   FAQ
Rab6b Gene Detail
Summary
  • Symbol
    Rab6b
  • Name
    RAB6B, member RAS oncogene family
  • Synonyms
    C330006L04Rik, D9Bwg0185e
  • Feature Type
    protein coding gene
  • IDs
    MGI:107283
    NCBI Gene: 270192
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:102988986-103062475 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 54.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2511 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107283
 protein coding gene Chr9:102988866-103062475 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035193
 protein coding gene Chr9:104714398-104791669 (+)
A/J MGP_AJ_G0035173
 protein coding gene Chr9:100945163-101022419 (+)
AKR/J MGP_AKRJ_G0035105
 protein coding gene Chr9:103443227-103520871 (+)
BALB/cJ MGP_BALBcJ_G0035166
 protein coding gene Chr9:100661168-100735818 (+)
C3H/HeJ MGP_C3HHeJ_G0034876
 protein coding gene Chr9:103838044-103912529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035686
 protein coding gene Chr9:107628334-107703791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032585
 protein coding gene Chr9:98532513-98604782 (+)
CAST/EiJ MGP_CASTEiJ_G0034188
 protein coding gene Chr9:103679934-103758731 (+)
CBA/J MGP_CBAJ_G0034845
 protein coding gene Chr9:111384784-111464880 (+)
DBA/2J MGP_DBA2J_G0035006
 protein coding gene Chr9:100439888-100513098 (+)
FVB/NJ MGP_FVBNJ_G0034954
 protein coding gene Chr9:99239137-99315361 (+)
LP/J MGP_LPJ_G0035082
 protein coding gene Chr9:104920907-104998131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034993
 protein coding gene Chr9:113193397-113268713 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035708
 protein coding gene Chr9:103688304-103771228 (+)
PWK/PhJ MGP_PWKPhJ_G0033895
 protein coding gene Chr9:100695751-100771209 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033730
 protein coding gene Chr9:103741018-103819977 (+)
WSB/EiJ MGP_WSBEiJ_G0034308
 protein coding gene Chr9:103578350-103657069 (+)



Homology
more
  • Human Ortholog
    RAB6B, RAB6B, member RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB6B, RAB6B, member RAS oncogene family
  • Links
    NCBI Gene ID: 51560
    neXtProt AC: NX_Q9NRW1
    UniProt: Q9NRW1

  • Chr Location
    3q22.1; chr3:133824235-133895882 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in growth retardation and multiple behavioral and immunological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    30
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032549 Ensembl Gene Model | MGI Sequence Detail 73490 C57BL/6J ±  kb
    transcript ENSMUST00000035155 Ensembl | MGI Sequence Detail 5007 Not Applicable  
    polypeptide ENSMUSP00000035155 Ensembl | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35748, MGI:1924738, MGI:2143137
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:354356 Zhang Y, et al., Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation. J Neurosci. 2024 Jul 3;44(27)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory