Ing4 MGI Mouse Gene Detail - MGI:107307 - inhibitor of growth family, member 4

Symbol

Ing4
Name

inhibitor of growth family, member 4
Synonyms

D6Wsu147e, D6Xrf92, p29ING4

Feature Type

protein coding gene
IDs

MGI:107307
NCBI Gene: 28019
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:125016811-125026228 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM
Mapping Data

4 experiments

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107307	protein coding gene	Chr6:125016723-125026228 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031282	protein coding gene	Chr6:128364015-128374746 (+)
A/J	MGP_AJ_G0031252	protein coding gene	Chr6:123521890-123531811 (+)
AKR/J	MGP_AKRJ_G0031180	protein coding gene	Chr6:126897678-126907882 (+)
BALB/cJ	MGP_BALBcJ_G0031260	protein coding gene	Chr6:123119229-123128516 (+)
C3H/HeJ	MGP_C3HHeJ_G0030983	protein coding gene	Chr6:126952480-126962114 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031716	protein coding gene	Chr6:131743527-131752948 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028866	protein coding gene	Chr6:120727867-120736633 (+)
CAST/EiJ	MGP_CASTEiJ_G0030364	protein coding gene	Chr6:127158910-127169213 (+)
CBA/J	MGP_CBAJ_G0030944	protein coding gene	Chr6:136783271-136796064 (+)
DBA/2J	MGP_DBA2J_G0031100	protein coding gene	Chr6:122453908-122463078 (+)
FVB/NJ	MGP_FVBNJ_G0031050	protein coding gene	Chr6:121360079-121369517 (+)
LP/J	MGP_LPJ_G0031180	protein coding gene	Chr6:128526962-128536461 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031088	protein coding gene	Chr6:140831510-140843797 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031751	protein coding gene	Chr6:126789319-126798461 (+)
PWK/PhJ	MGP_PWKPhJ_G0030079	protein coding gene	Chr6:120693272-120702572 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029908	protein coding gene	Chr6:124872669-124881481 (+)
WSB/EiJ	MGP_WSBEiJ_G0030449	protein coding gene	Chr6:127157604-127167565 (+)

Human Ortholog

ING4, inhibitor of growth family member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ING4, inhibitor of growth family member 4
Synonyms

my036, p29ING4
Links

HGNC:19423

NCBI Gene ID: 51147

neXtProt AC: NX_Q9UNL4

UniProt: Q9UNL4
Chr Location

12p13.31; chr12:6650301-6663142 (-) GRCh38

MGI Vertebrate Homology

Ing4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ING4
Gene Tree

Ing4

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele are hypersensitive to LPS challenge and exhibit elevated cytokine responses.

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All GO Annotations

58
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

902
Tissues

96
cDNA Data

167
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ing4

ZFIN ing4

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All Sequences

57
RefSeq

4
UniProt

1
CCDS

CCDS39632.1, CCDS90121.1

Ensembl

ENSMUSG00000030330 (Evidence)
NCBI Gene

28019

			Length	Strain/Species	Flank
genomic	28019	NCBI Gene Model \| MGI Sequence Detail	9418	C57BL/6J	± kb
transcript	NM_001368695	RefSeq \| MGI Sequence Detail	1621	ZRU/MplStud
polypeptide	Q8C0D7	UniProt \| EBI \| MGI Sequence Detail	249	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009036 inhibitor of growth protein 4

(term hierarchy)
PDB

1WEN, 1WEU
InterPro Domains

IPR028651 ING family

IPR024610 Inhibitor of growth protein, N-terminal histone-binding

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 171

cDNA 168

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-32273, MGD-MRK-35773, MGI:105232

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 8
Earliest

J:31523 Bassett DE Jr, et al., Comparative genomics, genome cross-referencing and XREFdb. Trends Genet. 1995 Sep;11(9):372-3
Latest

J:346139 Mah SYY, et al., ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development. 2024 Mar 1;151(5):dev202617

TSS for Ing4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58891	Chr6:125016793-125016822 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24