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Rtkn Gene Detail
Summary
  • Symbol
    Rtkn
  • Name
    rhotekin
  • Feature Type
    protein coding gene
  • IDs
    MGI:107371
    NCBI Gene: 20166
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83112485-83129560 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    398 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107371
 protein coding gene Chr6:83112444-83129560 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030923
 protein coding gene Chr6:84142313-84159355 (+)
A/J MGP_AJ_G0030892
 protein coding gene Chr6:80927880-80944878 (+)
AKR/J MGP_AKRJ_G0030820
 protein coding gene Chr6:83262591-83279565 (+)
BALB/cJ MGP_BALBcJ_G0030902
 protein coding gene Chr6:80948021-80965159 (+)
C3H/HeJ MGP_C3HHeJ_G0030808
 protein coding gene Chr6:101106882-101124835 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031362
 protein coding gene Chr6:86427217-86445746 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028548
 protein coding gene Chr6:79285976-79303401 (+)
CAST/EiJ MGP_CASTEiJ_G0030011
 protein coding gene Chr6:83265428-83282505 (+)
CBA/J MGP_CBAJ_G0030589
 protein coding gene Chr6:89840810-89860268 (+)
DBA/2J MGP_DBA2J_G0030742
 protein coding gene Chr6:80246836-80263975 (+)
FVB/NJ MGP_FVBNJ_G0030695
 protein coding gene Chr6:79454221-79471510 (+)
LP/J MGP_LPJ_G0030821
 protein coding gene Chr6:84134365-84152801 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030731
 protein coding gene Chr6:94155435-94173597 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031386
 protein coding gene Chr6:83075057-83094004 (+)
PWK/PhJ MGP_PWKPhJ_G0029726
 protein coding gene Chr6:79139707-79157674 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029554
 protein coding gene Chr6:81918638-81936561 (+)
WSB/EiJ MGP_WSBEiJ_G0030092
 protein coding gene Chr6:83510629-83529341 (+)



Homology
more
  • Human Ortholog
    RTKN, rhotekin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTKN, rhotekin
  • Synonyms
    RTKN-1
  • Links
    NCBI Gene ID: 6242
    neXtProt AC: NX_Q9BST9
    UniProt: Q9BST9

  • Chr Location
    2p13.1; chr2:74425835-74442422 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    6
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Rtkn
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    25 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    45
  • cDNA Data
    93
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20166 NCBI Gene Model | MGI Sequence Detail 17076 C57BL/6J ±  kb
transcript NM_133641 RefSeq | MGI Sequence Detail 3143 ZRU/MplStud  
polypeptide Q8C6B2 UniProt | EBI | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    Genomic 2
    cDNA 93
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35838
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:33389 Reid T, et al., Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem. 1996 Jun 7;271(23):13556-60
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory