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Il17ra Gene Detail
Summary
  • Symbol
    Il17ra
  • Name
    interleukin 17 receptor A
  • Synonyms
    Il17r, VDw217
  • Feature Type
    protein coding gene
  • IDs
    MGI:107399
    NCBI Gene: 16172
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:120440143-120460692 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.95 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107399
 protein coding gene Chr6:120440143-120464520 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031204
 protein coding gene Chr6:123355585-123380289 (+)
A/J MGP_AJ_G0031173
 protein coding gene Chr6:118612385-118638066 (+)
AKR/J MGP_AKRJ_G0031104
 protein coding gene Chr6:121812098-121840407 (+)
BALB/cJ MGP_BALBcJ_G0031184
 protein coding gene Chr6:118376555-118401058 (+)
C3H/HeJ MGP_C3HHeJ_G0030525
 protein coding gene Chr6:62473153-62497978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031642
 protein coding gene Chr6:126505235-126529320 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028802
 protein coding gene Chr6:115514678-115540100 (+)
CAST/EiJ MGP_CASTEiJ_G0030291
 protein coding gene Chr6:122250536-122280040 (+)
CBA/J MGP_CBAJ_G0030867
 protein coding gene Chr6:131534390-131559753 (+)
DBA/2J MGP_DBA2J_G0031023
 protein coding gene Chr6:117498011-117522763 (+)
FVB/NJ MGP_FVBNJ_G0030975
 protein coding gene Chr6:116627096-116652156 (+)
LP/J MGP_LPJ_G0031102
 protein coding gene Chr6:123344701-123370066 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031009
 protein coding gene Chr6:135518319-135543688 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031671
 protein coding gene Chr6:121835201-121860111 (+)
PWK/PhJ MGP_PWKPhJ_G0030006
 protein coding gene Chr6:116536953-116561370 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029835
 protein coding gene Chr6:120569224-120596078 (+)
WSB/EiJ MGP_WSBEiJ_G0030374
 protein coding gene Chr6:122124406-122153739 (+)



Homology
more
  • Human Ortholog
    IL17RA, interleukin 17 receptor A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17RA, interleukin 17 receptor A
  • Synonyms
    CANDF5, CD217, CDw217, hIL-17R, IL17R, IL-17RA, IMD51
  • Links
    NCBI Gene ID: 23765
    neXtProt AC: NX_Q96F46
    UniProt: Q96F46

  • Chr Location
    22q11.1; chr22:17084954-17115693 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL17RA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    198 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit delayed neutrophil recruitment and enhanced susceptibility to intranasal infection by Klibsiella pneumoniae. Mice homozygous for a different knock-out allele exhibit delayed and milder IMQ-induced psoriasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    3
  • cDNA Data
    57
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16172 NCBI Gene Model | MGI Sequence Detail 20550 C57BL/6J ±  kb
    transcript NM_008359 RefSeq | MGI Sequence Detail 3970 ZRU/MplStud  
    polypeptide Q60943 UniProt | EBI | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001375 interleukin-17 receptor A
      (term hierarchy)
    • InterPro Domains
      IPR038683 Interleukin-17 receptor A/B, FnIII-like domain 1 superfamily
      IPR043046 Interleukin-17 receptor A/B, FnIII-like domain 2 superfamily
      IPR032356 Interleukin-17 receptor, fibronectin-III-like domain 1
      IPR039465 Interleukin-17 receptor-like
      IPR013568 SEFIR domain
    • GlyGen
      Q60943 8 sites, 3 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 58
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35866, MGI:2141691
    References
    more
    • Summaries
      All 265
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 198
    • Earliest
      J:30252 Yao Z, et al., Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995 Dec;3(6):811-21
    • Latest
      J:354563 Santisteban MM, et al., Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. Nat Neurosci. 2024 Jan;27(1):63-77
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory