Elavl4 MGI Mouse Gene Detail - MGI:107427 - ELAV like RNA binding protein 4

Symbol

Elavl4
Name

ELAV like RNA binding protein 4
Synonyms

Hud

Feature Type

protein coding gene
IDs

MGI:107427
NCBI Gene: 15572
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:110060919-110209106 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 51.42 cM
Mapping Data

4 experiments

SNPs within 2kb

2916 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107427	protein coding gene	Chr4:110060919-110209127 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028576	protein coding gene	Chr4:110997102-111149165 (-)
A/J	MGP_AJ_G0028539	protein coding gene	Chr4:107001899-107147316 (-)
AKR/J	MGP_AKRJ_G0028486	protein coding gene	Chr4:109686055-109836888 (-)
BALB/cJ	MGP_BALBcJ_G0028558	protein coding gene	Chr4:107214829-107357111 (-)
C3H/HeJ	MGP_C3HHeJ_G0028272	protein coding gene	Chr4:110422888-110576990 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028998	protein coding gene	Chr4:114988631-115145269 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026289	protein coding gene	Chr4:102288809-102432191 (-)
CAST/EiJ	MGP_CASTEiJ_G0027708	protein coding gene	Chr4:108288003-108435596 (-)
CBA/J	MGP_CBAJ_G0028241	protein coding gene	Chr4:118772841-118925397 (-)
DBA/2J	MGP_DBA2J_G0028389	protein coding gene	Chr4:106625570-106779321 (-)
FVB/NJ	MGP_FVBNJ_G0028357	protein coding gene	Chr4:105488148-105629016 (-)
LP/J	MGP_LPJ_G0028490	protein coding gene	Chr4:111270968-111425252 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028383	protein coding gene	Chr4:123981090-124149536 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029034	protein coding gene	Chr4:109911926-110068417 (-)
PWK/PhJ	MGP_PWKPhJ_G0027434	protein coding gene	Chr4:104912930-105059414 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027258	protein coding gene	Chr4:107323628-107468251 (-)
WSB/EiJ	MGP_WSBEiJ_G0027789	protein coding gene	Chr4:110103873-110250843 (-)

Human Ortholog

ELAVL4, ELAV like RNA binding protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELAVL4, ELAV like RNA binding protein 4
Synonyms

HUD, PNEM
Links

HGNC:3315

NCBI Gene ID: 1996

neXtProt AC: NX_P26378

UniProt: P26378
Chr Location

1p33-p32.3; chr1:50024029-50203772 (+) GRCh38

MGI Vertebrate Homology

Elavl4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ELAVL4
Gene Tree

Elavl4

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Elavl4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display increased neural progenitor self-renewal and impaired neuronal differentiation, partial penetrance of hind limb clasping, and impaired coordination.

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All GO Annotations

54
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

937
Tissues

134
cDNA Data

53
Literature Summary

158

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase elavl4

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All Sequences

129
RefSeq

62
UniProt

8
CCDS

CCDS18470.1, CCDS18471.1, CCDS51261.1, CCDS51262.1, CCDS84777.1

Ensembl

ENSMUSG00000028546 (Evidence)
NCBI Gene

15572

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028546	Ensembl Gene Model \| MGI Sequence Detail	148188	C57BL/6J	± kb
transcript	ENSMUST00000106597	Ensembl \| MGI Sequence Detail	4149	Not Applicable
polypeptide	ENSMUSP00000102207	Ensembl \| MGI Sequence Detail	385	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007019 ELAV-like protein 4

(term hierarchy)
InterPro Domains

IPR034918 HuD, RNA recognition motif 3

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR002343 Paraneoplastic encephalomyelitis antigen

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR006548 Splicing factor ELAV/Hu
GlyGen

Q61701 1 site, 1 N-linked glycan (1 site)

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All nucleic 72

Genomic 6

cDNA 54

Primer pair 12

Microarray probesets 6

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MGD-MRK-35898

Summaries

All 222

Developmental Gene Expression 158

Gene Ontology 13

Phenotypes 22
Earliest

J:31495 Abe R, et al., Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. DNA Res. 1994;1(4):175-80
Latest

J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518

TSS for Elavl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42796	Chr4:110209107-110209142 (-)	-19 bp
Tssr42795	Chr4:110209087-110209102 (-)	11 bp
Tssr42794	Chr4:110149916-110149929 (-)	59,183 bp
Tssr42793	Chr4:110149698-110149701 (-)	59,406 bp
Tssr42792	Chr4:110148114-110148129 (-)	60,984 bp
Tssr42791	Chr4:110148081-110148110 (-)	61,010 bp
Tssr42790	Chr4:110144676-110144731 (-)	64,402 bp
Tssr42789	Chr4:110144051-110144083 (-)	65,039 bp
Tssr42788	Chr4:110143816-110143838 (-)	65,279 bp
Tssr42787	Chr4:110143778-110143814 (-)	65,310 bp
Tssr42786	Chr4:110143716-110143727 (-)	65,384 bp
Tssr42785	Chr4:110091577-110091584 (-)	117,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24