Cdh10 MGI Mouse Gene Detail - MGI:107436

Symbol

Cdh10
Name

cadherin 10
Synonyms

A830016G23Rik, C030003B10Rik, C030011H18Rik, T2-cadherin

Feature Type

protein coding gene
IDs

MGI:107436
NCBI Gene: 320873
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:18819033-19014322 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 8.20 cM
Mapping Data

2 experiments

SNPs within 2kb

5882 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107436	protein coding gene	Chr15:18818763-19014883 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021743	protein coding gene	Chr15:16419438-16637701 (+)
A/J	MGP_AJ_G0021703	protein coding gene	Chr15:15855310-16053045 (+)
AKR/J	MGP_AKRJ_G0021681	protein coding gene	Chr15:16242803-16432514 (+)
BALB/cJ	MGP_BALBcJ_G0021710	protein coding gene	Chr15:15849142-16045374 (+)
C3H/HeJ	MGP_C3HHeJ_G0021486	protein coding gene	Chr15:16257145-16454818 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022149	protein coding gene	Chr15:17105088-17316098 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019690	protein coding gene	Chr15:14878835-15070022 (+)
CAST/EiJ	MGP_CASTEiJ_G0021002	protein coding gene	Chr15:16592686-16798577 (+)
CBA/J	MGP_CBAJ_G0021455	protein coding gene	Chr15:17742226-17943473 (+)
DBA/2J	MGP_DBA2J_G0021579	protein coding gene	Chr15:15683519-15879282 (+)
FVB/NJ	MGP_FVBNJ_G0021557	protein coding gene	Chr15:15385049-15581002 (+)
LP/J	MGP_LPJ_G0021647	protein coding gene	Chr15:16348514-16567071 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021582	protein coding gene	Chr15:19181022-19431743 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022172	protein coding gene	Chr15:16368477-16573441 (+)
PWK/PhJ	MGP_PWKPhJ_G0020745	protein coding gene	Chr15:15938985-16138286 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020583	protein coding gene	Chr15:16235144-16433718 (+)
WSB/EiJ	MGP_WSBEiJ_G0021058	protein coding gene	Chr15:16291353-16500009 (+)

Human Ortholog

CDH10, cadherin 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDH10, cadherin 10
Links

HGNC:1749

NCBI Gene ID: 1008

neXtProt AC: NX_Q9Y6N8

UniProt: Q9Y6N8
Chr Location

5p14.2-p14.1; chr5:24487100-24644978 (-) GRCh38

MGI Vertebrate Homology

Cdh10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDH10
Gene Tree

Cdh10

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

8
Genomic Mutations

1 involving Cdh10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

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All GO Annotations

26
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1031
Tissues

218
cDNA Data

16
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDH10

Xenbase cdh10

ZFIN cdh10a

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All Sequences

52
RefSeq

6
UniProt

4
CCDS

CCDS37047.1

Ensembl

ENSMUSG00000022321 (Evidence)
NCBI Gene

320873

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022321	Ensembl Gene Model \| MGI Sequence Detail	195290	C57BL/6J	± kb
transcript	ENSMUST00000166873	Ensembl \| MGI Sequence Detail	3176	Not Applicable
polypeptide	ENSMUSP00000128782	Ensembl \| MGI Sequence Detail	788	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005229 cadherin-10

(term hierarchy)
PDB

6CG6
InterPro Domains

IPR039808 Cadherin

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR000233 Cadherin, Y-type LIR-motif

IPR027397 Catenin binding domain superfamily
GlyGen

P70408 4 sites, 12 N-linked glycans (4 sites)

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All nucleic 27

cDNA 20

Primer pair 6

Other 1

Microarray probesets 3

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MGD-MRK-35907, MGI:1924570, MGI:1925944, MGI:2444931

Summaries

All 62

Developmental Gene Expression 23

Gene Ontology 5

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059

TSS for Cdh10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130761	Chr15:18818750-18818777 (+)	-269 bp
Tssr130762	Chr15:18818786-18818812 (+)	-234 bp
Tssr130763	Chr15:18818981-18819028 (+)	-28 bp
Tssr130764	Chr15:18819039-18819048 (+)	11 bp
Tssr4558	Chr15:18820835-18820838 (+)	1,804 bp
Tssr130765	Chr15:18923423-18923427 (+)	104,392 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24