Fpr1 MGI Mouse Gene Detail - MGI:107443 - formyl peptide receptor 1

Symbol

Fpr1
Name

formyl peptide receptor 1
Synonyms

fMLF-R, FPR

Feature Type

protein coding gene
IDs

MGI:107443
NCBI Gene: 14293
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:18096733-18104201 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 10.63 cM
Mapping Data

4 experiments

SNPs within 2kb

282 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107443	protein coding gene	Chr17:18096733-18104202 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023186	protein coding gene	Chr17:15882872-15890348 (-)
A/J	MGP_AJ_G0023151	protein coding gene	Chr17:15528112-15535557 (-)
AKR/J	MGP_AKRJ_G0023121	protein coding gene	Chr17:15603569-15611007 (-)
BALB/cJ	MGP_BALBcJ_G0023151	protein coding gene	Chr17:15473443-15480972 (-)
C3H/HeJ	MGP_C3HHeJ_G0022911	protein coding gene	Chr17:15829870-15840102 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023594	protein coding gene	Chr17:16671339-16679037 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021106	protein coding gene	Chr17:13375683-13383193 (-)
CAST/EiJ	MGP_CASTEiJ_G0022430	protein coding gene	Chr17:15638733-15646167 (-)
CBA/J	MGP_CBAJ_G0022888	protein coding gene	Chr17:17240709-17248384 (-)
DBA/2J	MGP_DBA2J_G0023021	protein coding gene	Chr17:15242286-15249753 (-)
FVB/NJ	MGP_FVBNJ_G0022989	protein coding gene	Chr17:15055682-15063631 (-)
LP/J	MGP_LPJ_G0023095	protein coding gene	Chr17:15876623-15884073 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023010	protein coding gene	Chr17:16831222-16838634 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023631	protein coding gene	Chr17:15795074-15802543 (-)
PWK/PhJ	MGP_PWKPhJ_G0022179	protein coding gene	Chr17:14875525-14882987 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022007	protein coding gene	Chr17:14884761-14892848 (-)
WSB/EiJ	MGP_WSBEiJ_G0022489	protein coding gene	Chr17:16079264-16086737 (-)

Human Ortholog

FPR1, formyl peptide receptor 1

Vertebrate Orthologs

10

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FPR1, formyl peptide receptor 1
Synonyms

FMLP, FPR
Links

HGNC:3826

NCBI Gene ID: 2357

neXtProt AC: NX_P21462

UniProt: P21462
Chr Location

19q13.41; chr19:51745172-51804115 (-) GRCh38

MGI Vertebrate Homology

Fpr1 stringent orthology
1 human;1 mouse;1 rat;8 zebrafish
HCOP

vertebrate homology predictions: FPR1
Gene Tree

Fpr1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

1 involving Fpr1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

Targeted null mice are viable and developmentally normal but show increased susceptibility to L. monocytogenes challenge, as shown by increased mortality and bacterial burden in liver/spleen early post-infection. Mutant neutrophils fail to respond to fMLF either in calcium flux or chemotaxis assays.

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

5
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN fpr1

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS28418.1

Ensembl

ENSMUSG00000045551 (Evidence)
NCBI Gene

14293

			Length	Strain/Species	Flank
genomic	14293	NCBI Gene Model \| MGI Sequence Detail	7469	C57BL/6J	± kb
transcript	NM_013521	RefSeq \| MGI Sequence Detail	1332	ZRU/MplStud
polypeptide	P33766	UniProt \| EBI \| MGI Sequence Detail	364	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001580 fMet-Leu-Phe receptor

(term hierarchy)
InterPro Domains

IPR000826 Formyl peptide receptor-related

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P33766 3 sites

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All nucleic 16

Genomic 7

cDNA 8

Primer pair 1

Microarray probesets 4

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MGD-MRK-35914

Summaries

All 80

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 42
Earliest

J:43394 Gao JL, et al., Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains. J Biol Chem. 1993 Dec 5;268(34):25395-401
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fpr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146575	Chr17:18104225-18104236 (-)	-30 bp
Tssr146574	Chr17:18104182-18104216 (-)	2 bp
Tssr146573	Chr17:18097797-18097814 (-)	6,395 bp
Tssr146572	Chr17:18097367-18097387 (-)	6,824 bp
Tssr146571	Chr17:18097280-18097293 (-)	6,914 bp
Tssr146570	Chr17:18097253-18097264 (-)	6,942 bp
Tssr146569	Chr17:18096968-18096980 (-)	7,227 bp
Tssr146568	Chr17:18096930-18096942 (-)	7,265 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24