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Efna5 Gene Detail
Summary
  • Symbol
    Efna5
  • Name
    ephrin A5
  • Synonyms
    AL-1, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107444
    NCBI Gene: 13640
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:62911179-63188312 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 32.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6736 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107444
 protein coding gene Chr17:62909949-63188431 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023969
 protein coding gene Chr17:64633405-64923683 (-)
A/J MGP_AJ_G0023927
 protein coding gene Chr17:62719183-62999446 (-)
AKR/J MGP_AKRJ_G0023896
 protein coding gene Chr17:63562202-63841976 (-)
BALB/cJ MGP_BALBcJ_G0023928
 protein coding gene Chr17:62630027-62910269 (-)
C3H/HeJ MGP_C3HHeJ_G0023692
 protein coding gene Chr17:64426490-64717399 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024374
 protein coding gene Chr17:67152540-67444181 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021820
 protein coding gene Chr17:58877479-59161536 (-)
CAST/EiJ MGP_CASTEiJ_G0023174
 protein coding gene Chr17:64753707-65050407 (-)
CBA/J MGP_CBAJ_G0023668
 protein coding gene Chr17:69817071-70130103 (-)
DBA/2J MGP_DBA2J_G0023796
 protein coding gene Chr17:61488472-61765663 (-)
FVB/NJ MGP_FVBNJ_G0023762
 protein coding gene Chr17:60974676-61253314 (-)
LP/J MGP_LPJ_G0023878
 protein coding gene Chr17:65372994-65666480 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023790
 protein coding gene Chr17:69956932-70250010 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024418
 protein coding gene Chr17:64033356-64324075 (-)
PWK/PhJ MGP_PWKPhJ_G0022920
 protein coding gene Chr17:60743835-61031008 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022731
 protein coding gene Chr17:60717051-61003328 (-)
WSB/EiJ MGP_WSBEiJ_G0023240
 protein coding gene Chr17:64669347-64957768 (-)



Homology
more
  • Human Ortholog
    EFNA5, ephrin A5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFNA5, ephrin A5
  • Synonyms
    AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
  • Links
    NCBI Gene ID: 1946
    neXtProt AC: NX_P52803
    UniProt: P52803

  • Chr Location
    5q21.3; chr5:107376894-107670937 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Efna5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show defects in establishing axonal connections involving retinal, motor, vomeronasal and tactile axons to their respective targets. Some mice develop neural tube defects. Females show subfertility, impaired response to hCG, follicle rupture defects, and reduced ovulatory capacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1315
  • Tissues
    367
  • cDNA Data
    20
  • Literature Summary
    113
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048915 Ensembl Gene Model | MGI Sequence Detail 277134 C57BL/6J ±  kb
    transcript ENSMUST00000076840 Ensembl | MGI Sequence Detail 4032 Not Applicable  
    polypeptide ENSMUSP00000076115 Ensembl | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 25
      Primer pair 4
      Other 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35915, MGI:2147024
    References
    more
    • Summaries
      All 214
      Developmental Gene Expression 113
      Diseases 1
      Gene Ontology 16
      Phenotypes 76
    • Earliest
      J:34141 Cerretti DP, et al., The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17. Genomics. 1996 Jul 15;35(2):376-9
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory