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Clgn Gene Detail
Summary
  • Symbol
    Clgn
  • Name
    calmegin
  • Synonyms
    4930459O04Rik, A2/6, calnexin-t, Cln
  • Feature Type
    protein coding gene
  • IDs
    MGI:107472
    NCBI Gene: 12745
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84116496-84155181 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 39.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1080 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107472
 protein coding gene Chr8:84116454-84155181 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033831
 protein coding gene Chr8:84196322-84237978 (+)
A/J MGP_AJ_G0033814
 protein coding gene Chr8:80911088-80952248 (+)
AKR/J MGP_AKRJ_G0033740
 protein coding gene Chr8:83295003-83335806 (+)
BALB/cJ MGP_BALBcJ_G0033807
 protein coding gene Chr8:81024645-81062674 (+)
C3H/HeJ MGP_C3HHeJ_G0033516
 protein coding gene Chr8:83926459-83971523 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034327
 protein coding gene Chr8:87442178-87483061 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031268
 protein coding gene Chr8:74748176-74784875 (+)
CAST/EiJ MGP_CASTEiJ_G0032847
 protein coding gene Chr8:83320806-83358142 (+)
CBA/J MGP_CBAJ_G0033495
 protein coding gene Chr8:90567975-90628511 (+)
DBA/2J MGP_DBA2J_G0033648
 protein coding gene Chr8:80554849-80592607 (+)
FVB/NJ MGP_FVBNJ_G0033593
 protein coding gene Chr8:79473670-79515690 (+)
LP/J MGP_LPJ_G0033738
 protein coding gene Chr8:84329665-84368403 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033636
 protein coding gene Chr8:93078922-93124883 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034344
 protein coding gene Chr8:83297044-83335660 (+)
PWK/PhJ MGP_PWKPhJ_G0032550
 protein coding gene Chr8:79773979-79814969 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032388
 protein coding gene Chr8:82096207-82129826 (+)
WSB/EiJ MGP_WSBEiJ_G0032960
 protein coding gene Chr8:83684574-83726318 (+)



Homology
more
  • Human Ortholog
    CLGN, calmegin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLGN, calmegin
  • Links
    NCBI Gene ID: 1047
    neXtProt AC: NX_O14967
    UniProt: O14967

  • Chr Location
    4q31.1; chr4:140388453-140427661 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation exhibit severely impaired fertility associated with an apparent defect in either sperm/zona pellucida binding and/or sperm transit to the oviduct.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    47
  • cDNA Data
    14
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002190 Ensembl Gene Model | MGI Sequence Detail 38686 C57BL/6J ±  kb
    transcript ENSMUST00000002259 Ensembl | MGI Sequence Detail 3902 Not Applicable  
    polypeptide ENSMUSP00000002259 Ensembl | MGI Sequence Detail 611 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-2017, MGD-MRK-36039, MGI:1922128, MGI:2142583
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 11
      Gene Ontology 13
      Phenotypes 44
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory