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Cd38 Gene Detail
Summary
  • Symbol
    Cd38
  • Name
    CD38 antigen
  • Synonyms
    Cd38-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107474
    NCBI Gene: 12494
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:44026153-44069714 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 23.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1515 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107474
 protein coding gene Chr5:44025895-44069717 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029526
 protein coding gene Chr5:42501792-42546436 (+)
A/J MGP_AJ_G0029492
 protein coding gene Chr5:41031779-41076965 (+)
AKR/J MGP_AKRJ_G0029442
 protein coding gene Chr5:42492777-42537598 (+)
BALB/cJ MGP_BALBcJ_G0029503
 protein coding gene Chr5:41511304-41555572 (+)
C3H/HeJ MGP_C3HHeJ_G0029226
 protein coding gene Chr5:42468048-42512948 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029957
 protein coding gene Chr5:44554010-44597755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027196
 protein coding gene Chr5:38263440-38310042 (+)
CAST/EiJ MGP_CASTEiJ_G0028634
 protein coding gene Chr5:41583245-41629165 (+)
CBA/J MGP_CBAJ_G0029195
 protein coding gene Chr5:45728622-45774852 (+)
DBA/2J MGP_DBA2J_G0029340
 protein coding gene Chr5:41130553-41175010 (+)
FVB/NJ MGP_FVBNJ_G0029301
 protein coding gene Chr5:40554400-40600722 (+)
LP/J MGP_LPJ_G0029426
 protein coding gene Chr5:42970797-43014490 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029329
 protein coding gene Chr5:46543437-46590041 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029990
 protein coding gene Chr5:41984028-42029448 (+)
PWK/PhJ MGP_PWKPhJ_G0028358
 protein coding gene Chr5:40258786-40304298 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028192
 protein coding gene Chr5:41415237-41462747 (+)
WSB/EiJ MGP_WSBEiJ_G0028715
 protein coding gene Chr5:42068156-42115378 (+)



Homology
more
  • Human Ortholog
    CD38, CD38 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD38, CD38 molecule
  • Synonyms
    ADPRC 1, ADPRC1, cADPR1
  • Links
    NCBI Gene ID: 952
    neXtProt AC: NX_P28907
    UniProt: P28907

  • Chr Location
    4p15.32; chr4:15778275-15853232 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cd38 mouse models; 2 with human CD38 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    142 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene has resulted in an impaired antibody response to T cell dependent antigens and disrupted glucose-dependent insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    144
  • cDNA Data
    30
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12494 NCBI Gene Model | MGI Sequence Detail 43562 C57BL/6J ±  kb
    transcript NM_007646 RefSeq | MGI Sequence Detail 3009 ZRU/MplStud  
    polypeptide P56528 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 32
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1851, MGD-MRK-36041
    References
    more
    • Summaries
      All 213
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 12
      Phenotypes 142
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:354518 Pang Y, et al., CD38 Deficiency Protects Mouse Retinal Ganglion Cells Through Activating the NAD+/Sirt1 Pathway in Ischemia-Reperfusion and Optic Nerve Crush Models. Invest Ophthalmol Vis Sci. 2024 May 1;65(5):36
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory