Rgl2 MGI Mouse Gene Detail - MGI:107483 - ral guanine nucleotide dissociation stimulator-like 2

Symbol

Rgl2
Name

ral guanine nucleotide dissociation stimulator-like 2
Synonyms

KE1.5, Rab2l, Rgt2, Rlf

Feature Type

protein coding gene
IDs

MGI:107483
NCBI Gene: 19732
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:34148813-34156661 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM, cytoband B2
Mapping Data

2 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107483	protein coding gene	Chr17:34148517-34156661 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023544	protein coding gene	Chr17:33878639-33886774 (+)
A/J	MGP_AJ_G0023505	protein coding gene	Chr17:32712071-32720179 (+)
AKR/J	MGP_AKRJ_G0023471	protein coding gene	Chr17:33107708-33115812 (+)
BALB/cJ	MGP_BALBcJ_G0023508	protein coding gene	Chr17:32885162-32893292 (+)
C3H/HeJ	MGP_C3HHeJ_G0023270	protein coding gene	Chr17:33463082-33471190 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023950	protein coding gene	Chr17:35132205-35140335 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021424	protein coding gene	Chr17:30214809-30223203 (+)
CAST/EiJ	MGP_CASTEiJ_G0022772	protein coding gene	Chr17:33537000-33545146 (+)
CBA/J	MGP_CBAJ_G0023247	protein coding gene	Chr17:36561087-36572525 (+)
DBA/2J	MGP_DBA2J_G0023375	protein coding gene	Chr17:32089535-32097660 (+)
FVB/NJ	MGP_FVBNJ_G0023344	protein coding gene	Chr17:31948891-31956980 (+)
LP/J	MGP_LPJ_G0023453	protein coding gene	Chr17:34154322-34162332 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023366	protein coding gene	Chr17:35613575-35621664 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023991	protein coding gene	Chr17:33435878-33444028 (+)
PWK/PhJ	MGP_PWKPhJ_G0022520	protein coding gene	Chr17:31003709-31012007 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022336	protein coding gene	Chr17:31397878-31407193 (+)
WSB/EiJ	MGP_WSBEiJ_G0022832	protein coding gene	Chr17:33473743-33481930 (+)

Human Ortholog

RGL2, ral guanine nucleotide dissociation stimulator like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGL2, ral guanine nucleotide dissociation stimulator like 2
Synonyms

HKE1.5, KE1.5, RAB2L
Links

HGNC:9769

NCBI Gene ID: 5863

neXtProt AC: NX_O15211

UniProt: O15211
Chr Location

6p21.32; chr6:33291654-33301612 (-) GRCh38

MGI Vertebrate Homology

Rgl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RGL2
Gene Tree

Rgl2

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

12
Gene trapped

10
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

66
cDNA Data

85
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgl2

ZFIN rgl2

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All Sequences

68
RefSeq

18
UniProt

5
CCDS

CCDS28635.1

Ensembl

ENSMUSG00000041354 (Evidence)
NCBI Gene

19732

			Length	Strain/Species	Flank
genomic	19732	NCBI Gene Model \| MGI Sequence Detail	7849	C57BL/6J	± kb
transcript	NM_001410647	RefSeq \| MGI Sequence Detail	3053	C57BL/6
polypeptide	Q61193	UniProt \| EBI \| MGI Sequence Detail	778	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013937 Ral guanine nucleotide dissociation stimulator-like 2

(term hierarchy)
PDB

1RLF, 4JGW, 5CM8, 5CM9
InterPro Domains

IPR000159 Ras-associating domain

IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily

IPR019804 Ras guanine-nucleotide exchange factor, conserved site

IPR023578 Ras guanine nucleotide exchange factor domain superfamily

IPR001895 Ras guanine-nucleotide exchange factors catalytic domain

IPR008937 Ras-like guanine nucleotide exchange factor

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 88

cDNA 85

Primer pair 2

Other 1

Microarray probesets 2

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MGD-MRK-36051

Summaries

All 27

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 4
Earliest

J:34492 Wolthuis RM, et al., RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Oncogene. 1996 Jul 18;13(2):353-62
Latest

J:206030 Scotland RL, et al., The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits cardiac fibrosis. PLoS One. 2013;8(9):e73599

TSS for Rgl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143851	Chr17:34147129-34147224 (+)	-1,636 bp
Tssr143852	Chr17:34147244-34147275 (+)	-1,553 bp
Tssr143853	Chr17:34147449-34147451 (+)	-1,363 bp
Tssr143854	Chr17:34148488-34148560 (+)	-289 bp
Tssr143855	Chr17:34148868-34148891 (+)	67 bp
Tssr143856	Chr17:34148934-34148972 (+)	140 bp
Tssr143857	Chr17:34149820-34149904 (+)	1,049 bp
Tssr143858	Chr17:34150135-34150175 (+)	1,342 bp
Tssr143859	Chr17:34150333-34150347 (+)	1,527 bp
Tssr143860	Chr17:34154173-34154187 (+)	5,367 bp
Tssr143861	Chr17:34155588-34155592 (+)	6,777 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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