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Ralgds Gene Detail
Summary
  • Symbol
    Ralgds
  • Name
    ral guanine nucleotide dissociation stimulator
  • Synonyms
    Gnds, mKIAA1308, RalGDS, Rgds
  • Feature Type
    protein coding gene
  • IDs
    MGI:107485
    NCBI Gene: 19730
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:28403137-28443093 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    899 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107485
 protein coding gene Chr2:28403037-28443093 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025525
 protein coding gene Chr2:26570362-26614811 (+)
A/J MGP_AJ_G0025502
 protein coding gene Chr2:25566162-25606078 (+)
AKR/J MGP_AKRJ_G0025472
 protein coding gene Chr2:26412127-26452967 (+)
BALB/cJ MGP_BALBcJ_G0025498
 protein coding gene Chr2:25685745-25725666 (+)
C3H/HeJ MGP_C3HHeJ_G0025259
 protein coding gene Chr2:26335515-26377526 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025942
 protein coding gene Chr2:27472252-27514095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023352
 protein coding gene Chr2:24378941-24418188 (+)
CAST/EiJ MGP_CASTEiJ_G0024722
 protein coding gene Chr2:26237865-26279634 (+)
CBA/J MGP_CBAJ_G0025237
 protein coding gene Chr2:28398020-28444908 (+)
DBA/2J MGP_DBA2J_G0025370
 protein coding gene Chr2:25373931-25413918 (+)
FVB/NJ MGP_FVBNJ_G0025332
 protein coding gene Chr2:25151993-25198698 (+)
LP/J MGP_LPJ_G0025456
 protein coding gene Chr2:26526251-26569963 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025363
 protein coding gene Chr2:28402223-28447945 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026001
 protein coding gene Chr2:26326887-26366783 (+)
PWK/PhJ MGP_PWKPhJ_G0024469
 protein coding gene Chr2:25179185-25220133 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024269
 protein coding gene Chr2:26458744-26498853 (+)
WSB/EiJ MGP_WSBEiJ_G0024791
 protein coding gene Chr2:26459990-26499892 (+)



Homology
more
  • Human Ortholog
    RALGDS, ral guanine nucleotide dissociation stimulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RALGDS, ral guanine nucleotide dissociation stimulator
  • Synonyms
    RalGEF, RGDS, RGF
  • Links
    NCBI Gene ID: 5900
    neXtProt AC: NX_Q12967
    UniProt: Q12967

  • Chr Location
    9q34.13-q34.2; chr9:133097720-133149334 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit reduced tumor incidence, size and progression to malignancy in multistage skin carcinogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    33
  • cDNA Data
    175
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026821 Ensembl Gene Model | MGI Sequence Detail 39957 C57BL/6J ±  kb
transcript ENSMUST00000100241 Ensembl | MGI Sequence Detail 3102 Not Applicable  
polypeptide ENSMUSP00000097812 Ensembl | MGI Sequence Detail 907 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000013698 Ral guanine nucleotide dissociation stimulator
    (term hierarchy)
  • InterPro Domains
    IPR015758 Ral guanine nucleotide dissociation stimulator, RA domain
    IPR000159 Ras-associating domain
    IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    IPR029071 Ubiquitin-like domain superfamily
Molecular
Reagents
less
  • All nucleic 177
    cDNA 176
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36053
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:25192 Albright CF, et al., Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. EMBO J. 1993 Jan;12(1):339-47
  • Latest
    J:324845 Fernandez-Pisonero I, et al., A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors. Cell Rep. 2022 Mar 15;38(11):110522
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory