Wfdc18 MGI Mouse Gene Detail - MGI:107506 - WAP four-disulfide core domain 18

Symbol

Wfdc18
Name

WAP four-disulfide core domain 18
Synonyms

Expi, Kal1, WDNM1

Feature Type

protein coding gene
IDs

MGI:107506
NCBI Gene: 14038
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:83599841-83602174 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.23 cM, cytoband B5
Mapping Data

1 experiment

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107506	protein coding gene	Chr11:83599830-83602186 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018859	protein coding gene	Chr11:85089828-85092161 (+)
A/J	MGP_AJ_G0018826	protein coding gene	Chr11:81842249-81844582 (+)
AKR/J	MGP_AKRJ_G0018796	protein coding gene	Chr11:84270468-84272801 (+)
BALB/cJ	MGP_BALBcJ_G0018799	protein coding gene	Chr11:82239647-82241980 (+)
C3H/HeJ	MGP_C3HHeJ_G0018613	protein coding gene	Chr11:84323202-84325535 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019251	protein coding gene	Chr11:87663958-87666291 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016884	protein coding gene	Chr11:78945411-78947723 (+)
CAST/EiJ	MGP_CASTEiJ_G0018168	protein coding gene	Chr11:84944599-84946932 (+)
CBA/J	MGP_CBAJ_G0018584	protein coding gene	Chr11:91433369-91435702 (+)
DBA/2J	MGP_DBA2J_G0018692	protein coding gene	Chr11:81432940-81435273 (+)
FVB/NJ	MGP_FVBNJ_G0018681	protein coding gene	Chr11:80907838-80910171 (+)
LP/J	MGP_LPJ_G0018762	protein coding gene	Chr11:85625433-85627766 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018708	protein coding gene	Chr11:91599497-91601830 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019291	protein coding gene	Chr11:84542980-84545313 (+)
PWK/PhJ	MGP_PWKPhJ_G0017937	protein coding gene	Chr11:82184071-82186404 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017729	protein coding gene	Chr11:84085262-84087695 (+)
WSB/EiJ	MGP_WSBEiJ_G0018219	protein coding gene	Chr11:84393758-84396091 (+)

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Gene Tree

Wfdc18

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

2 involving Wfdc18
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

1
cDNA Data

87
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS25175.1

Ensembl

ENSMUSG00000000983 (Evidence)
NCBI Gene

14038

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000983	Ensembl Gene Model \| MGI Sequence Detail	2334	C57BL/6J	± kb
transcript	ENSMUST00000001009	Ensembl \| MGI Sequence Detail	521	Not Applicable
polypeptide	ENSMUSP00000001009	Ensembl \| MGI Sequence Detail	74	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007293 extracellular peptidase inhibitor

(term hierarchy)
InterPro Domains

IPR036645 Elafin-like superfamily

IPR008197 WAP-type 'four-disulfide core' domain

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All nucleic 89

Genomic 1

cDNA 87

Other 1

Microarray probesets 3

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MGD-MRK-36076

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wfdc18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103748	Chr11:83599919-83599922 (+)	80 bp
Tssr103749	Chr11:83599927-83599942 (+)	94 bp
Tssr103750	Chr11:83602050-83602058 (+)	2,213 bp
Tssr103751	Chr11:83602062-83602072 (+)	2,226 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24