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Ly6a Gene Detail
Summary
  • Symbol
    Ly6a
  • Name
    lymphocyte antigen 6 family member A
  • Synonyms
    Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca-1, Sca1, TAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107527
    NCBI Gene: 110454
  • Member of
    Ly6 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74866726-74869880 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107527
 protein coding gene Chr15:74866726-74869880 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021947
 protein coding gene Chr15:74821803-75371459 (-)
A/J MGP_AJ_G0021903
 protein coding gene Chr15:72163211-72165995 (-)
AKR/J MGP_AKRJ_G0021887
 protein coding gene Chr15:74032273-74035057 (-)
BALB/cJ MGP_BALBcJ_G0021912
 protein coding gene Chr15:72150407-72153191 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0022353
 protein coding gene Chr15:77640166-77645837 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019887
 protein coding gene Chr15:68555226-69086355 (-)
CAST/EiJ MGP_CASTEiJ_G0021204
 protein coding gene Chr15:74983715-75492969 (-)
CBA/J MGP_CBAJ_G0021651
 protein coding gene Chr15:80195643-80198427 (-)
DBA/2J MGP_DBA2J_G0021776
 protein coding gene Chr15:71745184-71746058 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0021848
 protein coding gene Chr15:74906627-75443869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021781
 protein coding gene Chr15:85507436-85511160 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0020945
 protein coding gene Chr15:71845002-72275922 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020789
 protein coding gene Chr15:74625223-74629055 (-)
WSB/EiJ MGP_WSBEiJ_G0021257
 protein coding gene Chr15:74468755-74952886 (-)



Homology
less
Human Diseases
more
  • Diseases
    1 with Ly6a mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    1 images
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show strain-dependent prenatal lethality, altered proliferative response by T lymphocytes, hematopoietic stem cell and progenitor defects, and age-related osteoporosis. Heterozygotes for a knock-in allele develop a myeloproliferative disorder and skin pathology at high penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    72
  • cDNA Data
    200
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110454 NCBI Gene Model | MGI Sequence Detail 3155 C57BL/6J ±  kb
    transcript NM_001271416 RefSeq | MGI Sequence Detail 1002 ZRU/MplStud  
    polypeptide P05533 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 206
      Genomic 2
      cDNA 200
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36097
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 44
      Diseases 2
      Gene Ontology 12
      Phenotypes 56
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:342315 Rao J, et al., Reconstructing human brown fat developmental trajectory in vitro. Dev Cell. 2023 Nov 6;58(21):2359-2375.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory