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Kpnb1 Gene Detail
Summary
  • Symbol
    Kpnb1
  • Name
    karyopherin subunit beta 1
  • Synonyms
    Impnb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107532
    NCBI Gene: 16211
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97050540-97078707 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.95 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107532
 protein coding gene Chr11:97050536-97078718 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019026
 protein coding gene Chr11:99550025-99576867 (-)
A/J MGP_AJ_G0018994
 protein coding gene Chr11:95474284-95499318 (-)
AKR/J MGP_AKRJ_G0018964
 protein coding gene Chr11:98435155-98463137 (-)
BALB/cJ MGP_BALBcJ_G0018967
 protein coding gene Chr11:95958459-95986907 (-)
C3H/HeJ MGP_C3HHeJ_G0018781
 protein coding gene Chr11:98544631-98574653 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019419
 protein coding gene Chr11:102636842-102666030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017050
 protein coding gene Chr11:92931464-92960172 (-)
CAST/EiJ MGP_CASTEiJ_G0018334
 protein coding gene Chr11:99396986-99428080 (-)
CBA/J MGP_CBAJ_G0018752
 protein coding gene Chr11:106861251-106893036 (-)
DBA/2J MGP_DBA2J_G0018860
 protein coding gene Chr11:95024160-95049658 (-)
FVB/NJ MGP_FVBNJ_G0018849
 protein coding gene Chr11:94503654-94531806 (-)
LP/J MGP_LPJ_G0018930
 protein coding gene Chr11:100077472-100108275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018876
 protein coding gene Chr11:106764717-106793798 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019459
 protein coding gene Chr11:98724604-98753025 (-)
PWK/PhJ MGP_PWKPhJ_G0018106
 protein coding gene Chr11:95999662-96026538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017896
 protein coding gene Chr11:98455415-98480911 (-)
WSB/EiJ MGP_WSBEiJ_G0018384
 protein coding gene Chr11:98636278-98661300 (-)



Homology
more
  • Human Ortholog
    KPNB1, karyopherin subunit beta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPNB1, karyopherin subunit beta 1
  • Synonyms
    IMB1, Impnb, IPO1, IPOB, NTF97
  • Links
    NCBI Gene ID: 3837
    neXtProt AC: NX_Q14974
    UniProt: Q14974

  • Chr Location
    17q21.32; chr17:47649476-47685505 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality shortly after implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    58
  • cDNA Data
    715
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001440 Ensembl Gene Model | MGI Sequence Detail 28168 C57BL/6J ±  kb
transcript ENSMUST00000001479 Ensembl | MGI Sequence Detail 5894 Not Applicable  
polypeptide ENSMUSP00000001479 Ensembl | MGI Sequence Detail 876 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 718
    cDNA 716
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36102, MGI:2144006
References
more
  • Summaries
    All 84
    Developmental Gene Expression 7
    Gene Ontology 25
    Phenotypes 20
  • Earliest
    J:320266 Moroianu J, et al., Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2008-11
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory