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Klrb1a Gene Detail
Summary
  • Symbol
    Klrb1a
  • Name
    killer cell lectin-like receptor subfamily B member 1A
  • Synonyms
    Ly55a, Nkrp1-a, NKR-P1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107540
    NCBI Gene: 17057
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128586190-128599897 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.06 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    600 from dbSNP Build 142
  • Strain Annotations
    16
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107540
 protein coding gene Chr6:128586190-128600496 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031330
 protein coding gene Chr6:132241806-132256123 (-)
A/J MGP_AJ_G0031301
 protein coding gene Chr6:127156772-127168920 (-)
AKR/J MGP_AKRJ_G0031229
 protein coding gene Chr6:130580457-130603832 (-)
BALB/cJ MGP_BALBcJ_G0031308
 protein coding gene Chr6:126735498-126759146 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0031767
 protein coding gene Chr6:135670981-135689022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028917
 protein coding gene Chr6:124679572-124681918 (-)
CAST/EiJ MGP_CASTEiJ_G0030413
 protein coding gene Chr6:131032034-131207169 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031149
 protein coding gene Chr6:126057479-126291637 (-)
FVB/NJ MGP_FVBNJ_G0031099
 protein coding gene Chr6:124981029-124996441 (-)
LP/J MGP_LPJ_G0031229
 protein coding gene Chr6:132352977-132366895 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031137
 protein coding gene Chr6:144742171-145008898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031800
 protein coding gene Chr6:130597412-130613389 (-)
PWK/PhJ MGP_PWKPhJ_G0030128
 protein coding gene Chr6:124359802-124553758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029959
 protein coding gene Chr6:128888647-128890939 (+)
WSB/EiJ MGP_WSBEiJ_G0030498
 protein coding gene Chr6:131010207-131020386 (-)



Homology
more
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Synonyms
    CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A, NKRP1A
  • Links
    NCBI Gene ID: 3820
    neXtProt AC: NX_Q12918
    UniProt: Q12918

  • Chr Location
    12p13.31; chr12:9594551-9607916 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17057 NCBI Gene Model | MGI Sequence Detail 13708 C57BL/6J ±  kb
transcript NM_010737 RefSeq | MGI Sequence Detail 1284 ZRU/MplStud  
polypeptide P27811 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 8
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36110
References
more
  • Summaries
    All 39
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:12581 Yokoyama WM, et al., cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 1;147(9):3229-36
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory