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Sox17 Gene Detail
Summary
  • Symbol
    Sox17
  • Name
    SRY (sex determining region Y)-box 17
  • Feature Type
    protein coding gene
  • IDs
    MGI:107543
    NCBI Gene: 20671
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:4561154-4567577 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107543
 protein coding gene Chr1:4561154-4567624 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015809
 protein coding gene Chr1:1522569-1528988 (-)
A/J MGP_AJ_G0015791
 protein coding gene Chr1:1599028-1605459 (-)
AKR/J MGP_AKRJ_G0015750
 protein coding gene Chr1:1571434-1579857 (-)
BALB/cJ MGP_BALBcJ_G0015747
 protein coding gene Chr1:1532575-1539078 (-)
C3H/HeJ MGP_C3HHeJ_G0015581
 protein coding gene Chr1:1555313-1561733 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016199
 protein coding gene Chr1:1599613-1606036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013921
 protein coding gene Chr1:1307477-1313908 (-)
CAST/EiJ MGP_CASTEiJ_G0015161
 protein coding gene Chr1:1727539-1733964 (-)
CBA/J MGP_CBAJ_G0015555
 protein coding gene Chr1:1708853-1715277 (-)
DBA/2J MGP_DBA2J_G0015653
 protein coding gene Chr1:1513623-1520047 (-)
FVB/NJ MGP_FVBNJ_G0015658
 protein coding gene Chr1:1481672-1488103 (-)
LP/J MGP_LPJ_G0015726
 protein coding gene Chr1:1702646-1710163 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015677
 protein coding gene Chr1:1858821-1865248 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016246
 protein coding gene Chr1:1525378-1531805 (-)
PWK/PhJ MGP_PWKPhJ_G0014945
 protein coding gene Chr1:1441874-1448358 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014725
 protein coding gene Chr1:1699686-1706124 (-)
WSB/EiJ MGP_WSBEiJ_G0015225
 protein coding gene Chr1:1535045-1541559 (-)



Homology
more
  • Human Ortholog
    SOX17, SRY-box transcription factor 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX17, SRY-box transcription factor 17
  • Synonyms
    VUR3
  • Links
    NCBI Gene ID: 64321
    neXtProt AC: NX_Q9H6I2
    UniProt: Q9H6I2

  • Chr Location
    8q11.23; chr8:54457935-54460892 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sox17 mouse models; 3 with human SOX17 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 8 alleles in 17 genetic backgrounds
    11 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1220
  • Tissues
    279
  • cDNA Data
    40
  • Literature Summary
    177
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025902 Ensembl Gene Model | MGI Sequence Detail 6424 C57BL/6J ±  kb
    transcript ENSMUST00000027035 Ensembl | MGI Sequence Detail 3127 Not Applicable  
    polypeptide ENSMUSP00000027035 Ensembl | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 40
      Primer pair 5
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36114
    References
    more
    • Summaries
      All 276
      Developmental Gene Expression 177
      Diseases 2
      Gene Ontology 31
      Phenotypes 86
    • Earliest
      J:33784 Kanai Y, et al., Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996 May;133(3):667-81
    • Latest
      J:358091 Arriagada C, et al., Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development. Dev Cell. 2024 Oct 14;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory