Traf5 MGI Mouse Gene Detail - MGI:107548 - TNF receptor-associated factor 5

Symbol

Traf5
Name

TNF receptor-associated factor 5

Feature Type

protein coding gene
IDs

MGI:107548
NCBI Gene: 22033
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:191729166-191776868 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 97.11 cM
Mapping Data

7 experiments

SNPs within 2kb

1060 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107548	protein coding gene	Chr1:191729164-191776899 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016951	protein coding gene	Chr1:199074035-199120790 (-)
A/J	MGP_AJ_G0016930	protein coding gene	Chr1:190903019-190950868 (-)
AKR/J	MGP_AKRJ_G0016895	protein coding gene	Chr1:196577599-196628772 (-)
BALB/cJ	MGP_BALBcJ_G0016888	protein coding gene	Chr1:191580653-191628815 (-)
C3H/HeJ	MGP_C3HHeJ_G0016712	protein coding gene	Chr1:197421132-197474484 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017351	protein coding gene	Chr1:205437396-205490906 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015058	protein coding gene	Chr1:181799286-181849556 (-)
CAST/EiJ	MGP_CASTEiJ_G0016295	protein coding gene	Chr1:197023490-197074639 (-)
CBA/J	MGP_CBAJ_G0016686	protein coding gene	Chr1:213039237-213091893 (-)
DBA/2J	MGP_DBA2J_G0016792	protein coding gene	Chr1:189625824-189676400 (-)
FVB/NJ	MGP_FVBNJ_G0016788	protein coding gene	Chr1:187752061-187798809 (-)
LP/J	MGP_LPJ_G0016867	protein coding gene	Chr1:200258497-200309965 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016820	protein coding gene	Chr1:219675624-219725451 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017388	protein coding gene	Chr1:196456851-196503515 (-)
PWK/PhJ	MGP_PWKPhJ_G0016082	protein coding gene	Chr1:188927660-188975616 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015858	protein coding gene	Chr1:195459288-195505106 (-)
WSB/EiJ	MGP_WSBEiJ_G0016357	protein coding gene	Chr1:196695286-196746229 (-)

Human Ortholog

TRAF5, TNF receptor associated factor 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAF5, TNF receptor associated factor 5
Synonyms

MGC:39780, RNF84
Links

HGNC:12035

NCBI Gene ID: 7188

neXtProt AC: NX_O00463

UniProt: O00463
Chr Location

1q32.3; chr1:211326615-211374946 (+) GRCh38

MGI Vertebrate Homology

Traf5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRAF5
Protein SuperFamily

TRAF
Gene Tree

Traf5

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show defects in lymphocyte activation but are otherwise viable and develop normally.

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All GO Annotations

38
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

17
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase traf5

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All Sequences

42
RefSeq

6
UniProt

3

Ensembl

ENSMUSG00000026637 (Evidence)
NCBI Gene

22033

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026637	Ensembl Gene Model \| MGI Sequence Detail	47703	C57BL/6J	± kb
transcript	ENSMUST00000195815	Ensembl \| MGI Sequence Detail	2214	Not Applicable
polypeptide	ENSMUSP00000141931	Ensembl \| MGI Sequence Detail	558	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000002291 TNF receptor-associated factor 5

(term hierarchy)
PDB

4GJH
EC

2.3.2.27
InterPro Domains

IPR002083 MATH/TRAF domain

IPR049440 TNF receptor-associated factor 3/5, RING domain

IPR027130 TNF receptor-associated factor 5, C3HC3D-type RING-HC finger

IPR012227 TNF receptor-associated factor TRAF, metazoa

IPR049342 TRAF1-6/MEP1A/B-like, MATH domain

IPR008974 TRAF-like

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR001293 Zinc finger, TRAF-type

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All nucleic 15

cDNA 15

Microarray probesets 4

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MGD-MRK-36119

Summaries

All 65

Developmental Gene Expression 2

Gene Ontology 13

Phenotypes 24
Earliest

J:33749 Nakano H, et al., TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem. 1996 Jun 21;271(25):14661-4
Latest

J:322305 Kawahara E, et al., TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4(+) T Lymphocytes. J Immunol. 2022 Feb 1;208(3):642-650

TSS for Traf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15820	Chr1:191776840-191776919 (-)	-12 bp
Tssr15819	Chr1:191776758-191776769 (-)	104 bp
Tssr15818	Chr1:191776727-191776755 (-)	127 bp
Tssr15817	Chr1:191776720-191776725 (-)	145 bp
Tssr15816	Chr1:191776666-191776675 (-)	197 bp
Tssr15811	Chr1:191748911-191748941 (-)	27,942 bp
Tssr15810	Chr1:191746123-191746144 (-)	30,734 bp
Tssr15809	Chr1:191746022-191746036 (-)	30,839 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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