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Sema3b Gene Detail
Summary
  • Symbol
    Sema3b
  • Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
  • Synonyms
    LUCA-1, SemA, SemA, sema5, Semaa, semaV
  • Feature Type
    protein coding gene
  • IDs
    MGI:107561
    NCBI Gene: 20347
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107474873-107486428 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.31 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107561
 protein coding gene Chr9:107474868-107486440 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035264
 protein coding gene Chr9:109484878-109496432 (-)
A/J MGP_AJ_G0035243
 protein coding gene Chr9:105495561-105507132 (-)
AKR/J MGP_AKRJ_G0035175
 protein coding gene Chr9:108128504-108140071 (-)
BALB/cJ MGP_BALBcJ_G0035237
 protein coding gene Chr9:105164105-105175658 (-)
C3H/HeJ MGP_C3HHeJ_G0034947
 protein coding gene Chr9:108526591-108538142 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035757
 protein coding gene Chr9:112465339-112476892 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032655
 protein coding gene Chr9:102924041-102935796 (-)
CAST/EiJ MGP_CASTEiJ_G0034258
 protein coding gene Chr9:108460399-108471949 (-)
CBA/J MGP_CBAJ_G0034915
 protein coding gene Chr9:116438385-116449931 (-)
DBA/2J MGP_DBA2J_G0035076
 protein coding gene Chr9:104948343-104959900 (-)
FVB/NJ MGP_FVBNJ_G0035024
 protein coding gene Chr9:103714924-103726523 (-)
LP/J MGP_LPJ_G0035152
 protein coding gene Chr9:109680151-109691704 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035063
 protein coding gene Chr9:118053972-118065522 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035778
 protein coding gene Chr9:108402474-108414039 (-)
PWK/PhJ MGP_PWKPhJ_G0033965
 protein coding gene Chr9:105269111-105280746 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033800
 protein coding gene Chr9:108454198-108465717 (-)
WSB/EiJ MGP_WSBEiJ_G0034379
 protein coding gene Chr9:108282220-108293741 (-)



Homology
more
  • Human Ortholog
    SEMA3B, semaphorin 3B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA3B, semaphorin 3B
  • Synonyms
    LUCA-1, SemA, SEMA5, SEMAA, semaV
  • Links
    NCBI Gene ID: 7869
    neXtProt AC: NX_Q13214
    UniProt: Q13214

  • Chr Location
    3p21.31; chr3:50267558-50277546 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele are viable and fertile with no obvious pathological abnormalities. Mice homozygous for a second knock-out allele exhibit improper positioning of a major brain commissural projection, the anterior commissure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    108
  • cDNA Data
    57
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057969 Ensembl Gene Model | MGI Sequence Detail 11556 C57BL/6J ±  kb
    transcript ENSMUST00000102532 Ensembl | MGI Sequence Detail 3191 Not Applicable  
    polypeptide ENSMUSP00000099591 Ensembl | MGI Sequence Detail 749 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 4
      cDNA 59
      Primer pair 4
      Other 8

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36132, MGI:2143295
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 42
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
    • Latest
      J:331696 Gerstmann K, et al., A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis. Sci Adv. 2022 Nov 16;8(46):eabo4552
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory