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Nab2 Gene Detail
Summary
  • Symbol
    Nab2
  • Name
    Ngfi-A binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107563
    NCBI Gene: 17937
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127496787-127502572 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107563
 protein coding gene Chr10:127496787-127504437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017829
 protein coding gene Chr10:131286611-131294271 (-)
A/J MGP_AJ_G0017804
 protein coding gene Chr10:126031913-126039567 (-)
AKR/J MGP_AKRJ_G0017767
 protein coding gene Chr10:129751564-129759233 (-)
BALB/cJ MGP_BALBcJ_G0017768
 protein coding gene Chr10:126434143-126441799 (-)
C3H/HeJ MGP_C3HHeJ_G0017592
 protein coding gene Chr10:129906605-129915201 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018223
 protein coding gene Chr10:135734529-135743769 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015903
 protein coding gene Chr10:120015792-120023419 (-)
CAST/EiJ MGP_CASTEiJ_G0017152
 protein coding gene Chr10:130570949-130578653 (-)
CBA/J MGP_CBAJ_G0017561
 protein coding gene Chr10:141208482-141219964 (-)
DBA/2J MGP_DBA2J_G0017667
 protein coding gene Chr10:125106582-125114234 (-)
FVB/NJ MGP_FVBNJ_G0017662
 protein coding gene Chr10:124048956-124056986 (-)
LP/J MGP_LPJ_G0017741
 protein coding gene Chr10:131861406-131869042 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017690
 protein coding gene Chr10:143888780-143896430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018263
 protein coding gene Chr10:129825784-129833434 (-)
PWK/PhJ MGP_PWKPhJ_G0016937
 protein coding gene Chr10:125314269-125322013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016729
 protein coding gene Chr10:128857367-128864971 (-)
WSB/EiJ MGP_WSBEiJ_G0017213
 protein coding gene Chr10:130048150-130055791 (-)



Homology
more
  • Human Ortholog
    NAB2, NGFI-A binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAB2, NGFI-A binding protein 2
  • Synonyms
    MADER
  • Links
    NCBI Gene ID: 4665
    neXtProt AC: NX_Q15742
    UniProt: Q15742

  • Chr Location
    12q13.3; chr12:57089043-57095476 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile with normal myelination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    26
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17937 NCBI Gene Model | MGI Sequence Detail 5786 C57BL/6J ±  kb
    transcript NM_008668 RefSeq | MGI Sequence Detail 2593 ZRU/MplStud  
    polypeptide Q61127 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 3
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36135, MGI:2143612
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:27421 Russo MW, et al., Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6873-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory