Nab2 MGI Mouse Gene Detail - MGI:107563 - Ngfi-A binding protein 2

Symbol

Nab2
Name

Ngfi-A binding protein 2

Feature Type

protein coding gene
IDs

MGI:107563
NCBI Gene: 17937
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr10:127496787-127502572 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.60 cM
Mapping Data

4 experiments

SNPs within 2kb

108 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107563	protein coding gene	Chr10:127496787-127504437 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017829	protein coding gene	Chr10:131286611-131294271 (-)
A/J	MGP_AJ_G0017804	protein coding gene	Chr10:126031913-126039567 (-)
AKR/J	MGP_AKRJ_G0017767	protein coding gene	Chr10:129751564-129759233 (-)
BALB/cJ	MGP_BALBcJ_G0017768	protein coding gene	Chr10:126434143-126441799 (-)
C3H/HeJ	MGP_C3HHeJ_G0017592	protein coding gene	Chr10:129906605-129915201 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018223	protein coding gene	Chr10:135734529-135743769 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015903	protein coding gene	Chr10:120015792-120023419 (-)
CAST/EiJ	MGP_CASTEiJ_G0017152	protein coding gene	Chr10:130570949-130578653 (-)
CBA/J	MGP_CBAJ_G0017561	protein coding gene	Chr10:141208482-141219964 (-)
DBA/2J	MGP_DBA2J_G0017667	protein coding gene	Chr10:125106582-125114234 (-)
FVB/NJ	MGP_FVBNJ_G0017662	protein coding gene	Chr10:124048956-124056986 (-)
LP/J	MGP_LPJ_G0017741	protein coding gene	Chr10:131861406-131869042 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017690	protein coding gene	Chr10:143888780-143896430 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018263	protein coding gene	Chr10:129825784-129833434 (-)
PWK/PhJ	MGP_PWKPhJ_G0016937	protein coding gene	Chr10:125314269-125322013 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016729	protein coding gene	Chr10:128857367-128864971 (-)
WSB/EiJ	MGP_WSBEiJ_G0017213	protein coding gene	Chr10:130048150-130055791 (-)

Human Ortholog

NAB2, NGFI-A binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAB2, NGFI-A binding protein 2
Synonyms

MADER
Links

HGNC:7627

NCBI Gene ID: 4665

neXtProt AC: NX_Q15742

UniProt: Q15742
Chr Location

12q13.3; chr12:57089043-57095476 (+) GRCh38

MGI Vertebrate Homology

Nab2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAB2
Gene Tree

Nab2

less

Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

4
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile with normal myelination.

less

All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

26
cDNA Data

13
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nab2

less

All Sequences

50
RefSeq

4
UniProt

7
CCDS

CCDS24247.1, CCDS48719.1

Ensembl

ENSMUSG00000025402 (Evidence)
NCBI Gene

17937

			Length	Strain/Species	Flank
genomic	17937	NCBI Gene Model \| MGI Sequence Detail	5786	C57BL/6J	± kb
transcript	NM_008668	RefSeq \| MGI Sequence Detail	2593	ZRU/MplStud
polypeptide	Q61127	UniProt \| EBI \| MGI Sequence Detail	525	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000010949 NGFI-A-binding protein 2

(term hierarchy)
InterPro Domains

IPR006989 NAB co-repressor, domain

IPR038398 NAB co-repressor domain 2 superfamily

IPR039040 NAB family

IPR006988 Nab, N-terminal

IPR013761 Sterile alpha motif/pointed domain superfamily

less

All nucleic 17

Genomic 3

cDNA 13

Primer pair 1

Microarray probesets 4

less

MGD-MRK-36135, MGI:2143612

Summaries

All 47

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 13
Earliest

J:27421 Russo MW, et al., Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6873-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nab2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99819	Chr10:127504390-127504458 (-)	-1,852 bp
Tssr99818	Chr10:127503518-127503534 (-)	-954 bp
Tssr99817	Chr10:127503452-127503479 (-)	-894 bp
Tssr99816	Chr10:127502763-127502806 (-)	-213 bp
Tssr99815	Chr10:127502653-127502686 (-)	-98 bp
Tssr99814	Chr10:127502542-127502615 (-)	-7 bp
Tssr99813	Chr10:127502467-127502492 (-)	92 bp
Tssr99812	Chr10:127499339-127499350 (-)	3,227 bp
Tssr99811	Chr10:127497522-127497536 (-)	5,043 bp
Tssr99810	Chr10:127497304-127497327 (-)	5,256 bp
Tssr99809	Chr10:127497284-127497293 (-)	5,283 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24