Kifap3 MGI Mouse Gene Detail - MGI:107566 - kinesin-associated protein 3

Symbol

Kifap3
Name

kinesin-associated protein 3
Synonyms

KAP3

Feature Type

protein coding gene
IDs

MGI:107566
NCBI Gene: 16579
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:163607152-163744678 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 71.08 cM, cytoband H1
Mapping Data

2 experiments

SNPs within 2kb

3362 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107566	protein coding gene	Chr1:163589711-163744678 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016673	protein coding gene	Chr1:169184863-169317045 (+)
A/J	MGP_AJ_G0016654	protein coding gene	Chr1:162276921-162422622 (+)
AKR/J	MGP_AKRJ_G0016620	protein coding gene	Chr1:167223145-167351085 (+)
BALB/cJ	MGP_BALBcJ_G0016615	protein coding gene	Chr1:162785249-162924759 (+)
C3H/HeJ	MGP_C3HHeJ_G0016439	protein coding gene	Chr1:167392766-167533618 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017076	protein coding gene	Chr1:174882039-175023465 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014785	protein coding gene	Chr1:154268938-154397095 (+)
CAST/EiJ	MGP_CASTEiJ_G0016019	protein coding gene	Chr1:167029236-167158871 (+)
CBA/J	MGP_CBAJ_G0016414	protein coding gene	Chr1:181110993-181247187 (+)
DBA/2J	MGP_DBA2J_G0016520	protein coding gene	Chr1:161204259-161326652 (+)
FVB/NJ	MGP_FVBNJ_G0016518	protein coding gene	Chr1:159629525-159764675 (+)
LP/J	MGP_LPJ_G0016591	protein coding gene	Chr1:170274482-170404623 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016543	protein coding gene	Chr1:188598939-188743439 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017112	protein coding gene	Chr1:167044752-167178280 (+)
PWK/PhJ	MGP_PWKPhJ_G0015805	protein coding gene	Chr1:160386420-160513341 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015592	protein coding gene	Chr1:165928944-166058207 (+)
WSB/EiJ	MGP_WSBEiJ_G0016081	protein coding gene	Chr1:167185262-167342733 (+)

Human Ortholog

KIFAP3, kinesin associated protein 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIFAP3, kinesin associated protein 3
Synonyms

dJ190I16.1, FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS
Links

HGNC:17060

NCBI Gene ID: 22920

neXtProt AC: NX_Q92845

UniProt: Q92845
Chr Location

1q24.2; chr1:169921326-170085208 (-) GRCh38

MGI Vertebrate Homology

Kifap3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIFAP3
Gene Tree

Kifap3

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Phenotype Summary

9 phenotypes from 3 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Gene trapped

4
Targeted

4
Genomic Mutations

2 involving Kifap3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.

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All GO Annotations

55
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

14
cDNA Data

132
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kifap3

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All Sequences

50
RefSeq

8
UniProt

3
CCDS

CCDS35751.1, CCDS78729.1

Ensembl

ENSMUSG00000026585 (Evidence)
NCBI Gene

16579

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026585	Ensembl Gene Model \| MGI Sequence Detail	137527	C57BL/6J	± kb
transcript	ENSMUST00000027877	Ensembl \| MGI Sequence Detail	3946	Not Applicable
polypeptide	ENSMUSP00000027877	Ensembl \| MGI Sequence Detail	793	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009322 kinesin-associated protein 3

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR008658 Kinesin-associated protein 3
GlyGen

P70188 1 site, 1 N-linked glycan (1 site)

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All nucleic 133

cDNA 132

Primer pair 1

Microarray probesets 5

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MGD-MRK-36138

Summaries

All 53

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 13
Earliest

J:34827 Yamazaki H, et al., Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8443-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kifap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9731	Chr1:163607128-163607139 (+)	-18 bp
Tssr9732	Chr1:163607144-163607161 (+)	1 bp
Tssr9733	Chr1:163607163-163607200 (+)	30 bp
Tssr9734	Chr1:163607204-163607274 (+)	87 bp
Tssr9735	Chr1:163607278-163607313 (+)	144 bp
Tssr9736	Chr1:163607314-163607332 (+)	171 bp
Tssr9737	Chr1:163607380-163607434 (+)	255 bp
Tssr264	Chr1:163715390-163715401 (+)	108,244 bp
Tssr9738	Chr1:163731252-163731257 (+)	124,103 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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