Xiap MGI Mouse Gene Detail - MGI:107572 - X-linked inhibitor of apoptosis

Symbol

Xiap
Name

X-linked inhibitor of apoptosis
Synonyms

1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1

Feature Type

protein coding gene
IDs

MGI:107572
NCBI Gene: 11798
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

ChrX:41148556-41198533 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 23.19 cM, cytoband A3-A5
Mapping Data

3 experiments

SNPs within 2kb

904 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107572	protein coding gene	ChrX:41148483-41198541 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035674	protein coding gene	ChrX:37121133-37174700 (+)
A/J	MGP_AJ_G0035657	protein coding gene	ChrX:37083874-37134989 (+)
AKR/J	MGP_AKRJ_G0035577	protein coding gene	ChrX:37981946-38034072 (+)
BALB/cJ	MGP_BALBcJ_G0035643	protein coding gene	ChrX:36771394-36822252 (+)
C3H/HeJ	MGP_C3HHeJ_G0035347	protein coding gene	ChrX:37439797-37491332 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036172	protein coding gene	ChrX:37935483-37985818 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033024	protein coding gene	ChrX:35198225-35248756 (+)
CAST/EiJ	MGP_CASTEiJ_G0034638	protein coding gene	ChrX:25273850-25326388 (+)
CBA/J	MGP_CBAJ_G0035321	protein coding gene	ChrX:38940233-38994403 (+)
DBA/2J	MGP_DBA2J_G0035475	protein coding gene	ChrX:36892217-36942453 (+)
FVB/NJ	MGP_FVBNJ_G0035424	protein coding gene	ChrX:36625141-36675123 (+)
LP/J	MGP_LPJ_G0035563	protein coding gene	ChrX:37439475-37489909 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035462	protein coding gene	ChrX:39684325-39738466 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036190	protein coding gene	ChrX:37076609-37128550 (+)
PWK/PhJ	MGP_PWKPhJ_G0034337	protein coding gene	ChrX:24819607-24869596 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034182	protein coding gene	ChrX:25831045-25891661 (+)
WSB/EiJ	MGP_WSBEiJ_G0034782	protein coding gene	ChrX:36718260-36770371 (+)

Human Ortholog

BIRC8, baculoviral IAP repeat containing 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BIRC8, baculoviral IAP repeat containing 8
Synonyms

hILP2, ILP-2, ILP2, RNF136
Links

HGNC:14878

NCBI Gene ID: 112401

UniProt: Q96P09
Chr Location

chr19:53289601-53291434 (-) GRCh38

Human Ortholog

XIAP, X-linked inhibitor of apoptosis
Synonyms

API3, BIRC4, hIAP-3, hIAP3, IAP-3, ILP1, MIHA, XLP2
Links

HGNC:592

NCBI Gene ID: 331

neXtProt AC: NX_P98170

UniProt: P98170
Chr Location

Xq25; chrX:123859708-123913972 (+) GRCh38

MGI Vertebrate Homology

Xiap stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BIRC8, XIAP
Gene Tree

Xiap

Diseases

2 with human XIAP associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				X-linked lymphoproliferative syndrome 2 IDs X-linked lymphoproliferative syndrome 2 DOID:0060706 ICD10CM:D82.3 OMIM:300635

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 3 alleles in 4 genetic backgrounds
15 phenotypes from multigenic genotypes
58 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

2
Gene trapped

44
Targeted

7
Incidental Mutations

APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants are indistinguishable from normal littermates, but increased levels of protein from other Birc gene family members suggest a compensatory mechanism in the absence of the Birc4 gene's product.

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All GO Annotations

55
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

817
Tissues

81
cDNA Data

123
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xiap

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All Sequences

106
RefSeq

41
UniProt

3
CCDS

CCDS30098.1

Ensembl

ENSMUSG00000025860 (Evidence)
NCBI Gene

11798

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025860	Ensembl Gene Model \| MGI Sequence Detail	49978	C57BL/6J	± kb
transcript	ENSMUST00000026978	Ensembl \| MGI Sequence Detail	6834	Not Applicable
polypeptide	ENSMUSP00000026978	Ensembl \| MGI Sequence Detail	496	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003119 baculoviral IAP repeat-containing protein 4

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR048875 BIRC2/3-like, UBA domain

IPR001370 BIR repeat

IPR050784 Inhibitor of Apoptosis

IPR042579 XIAP/BIRC8, UBA domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q60989 1 site, 1 N-linked glycan (1 site)

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All nucleic 130

Genomic 4

cDNA 123

Primer pair 3

Microarray probesets 11

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MGD-MRK-36144, MGI:1922024

Summaries

All 148

Developmental Gene Expression 19

Gene Ontology 16

Phenotypes 58
Earliest

J:33039 Uren AG, et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4974-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Xiap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160811	ChrX:41148407-41148417 (+)	-144 bp
Tssr160812	ChrX:41148480-41148541 (+)	-45 bp
Tssr160813	ChrX:41148781-41148803 (+)	236 bp
Tssr160814	ChrX:41149265-41149276 (+)	715 bp
Tssr160815	ChrX:41149299-41149316 (+)	752 bp
Tssr160816	ChrX:41155406-41155417 (+)	6,856 bp
Tssr160817	ChrX:41155426-41155438 (+)	6,876 bp
Tssr160818	ChrX:41155445-41155466 (+)	6,900 bp
Tssr160819	ChrX:41156716-41156749 (+)	8,177 bp
Tssr160820	ChrX:41156753-41156764 (+)	8,203 bp
Tssr160821	ChrX:41156836-41156875 (+)	8,300 bp
Tssr160822	ChrX:41156903-41156914 (+)	8,353 bp
Tssr160823	ChrX:41157099-41157109 (+)	8,548 bp
Tssr160824	ChrX:41157201-41157238 (+)	8,664 bp
Tssr160825	ChrX:41157243-41157265 (+)	8,698 bp
Tssr160826	ChrX:41157299-41157324 (+)	8,756 bp
Tssr160827	ChrX:41157327-41157349 (+)	8,782 bp
Tssr160828	ChrX:41157553-41157643 (+)	9,042 bp
Tssr160829	ChrX:41158341-41158346 (+)	9,788 bp
Tssr160830	ChrX:41164480-41164494 (+)	15,931 bp
Tssr160831	ChrX:41197249-41197261 (+)	48,699 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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