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Sipa1 Gene Detail
Summary
  • Symbol
    Sipa1
  • Name
    signal-induced proliferation associated gene 1
  • Synonyms
    SPA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107576
    NCBI Gene: 20469
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:5701213-5713735 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107576
 protein coding gene Chr19:5701211-5713758 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024720
 protein coding gene Chr19:2636330-2648837 (-)
A/J MGP_AJ_G0024686
 protein coding gene Chr19:2490278-2503266 (-)
AKR/J MGP_AKRJ_G0024659
 protein coding gene Chr19:2557083-2569696 (-)
BALB/cJ MGP_BALBcJ_G0024686
 protein coding gene Chr19:2484280-2497605 (-)
C3H/HeJ MGP_C3HHeJ_G0024454
 protein coding gene Chr19:2572611-2587890 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025133
 protein coding gene Chr19:2702618-2716489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022563
 protein coding gene Chr19:2399802-2412232 (-)
CAST/EiJ MGP_CASTEiJ_G0023926
 protein coding gene Chr19:2592518-2605076 (-)
CBA/J MGP_CBAJ_G0024426
 protein coding gene Chr19:2826150-2838656 (-)
DBA/2J MGP_DBA2J_G0024553
 protein coding gene Chr19:2486973-2499503 (-)
FVB/NJ MGP_FVBNJ_G0024519
 protein coding gene Chr19:2479998-2495824 (-)
LP/J MGP_LPJ_G0024639
 protein coding gene Chr19:2610553-2624193 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024549
 protein coding gene Chr19:2670407-2683808 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025181
 protein coding gene Chr19:2577759-2590229 (-)
PWK/PhJ MGP_PWKPhJ_G0023672
 protein coding gene Chr19:2508430-2521551 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023477
 protein coding gene Chr19:2559943-2573388 (-)
WSB/EiJ MGP_WSBEiJ_G0023988
 protein coding gene Chr19:2587507-2600044 (-)



Homology
more
  • Human Ortholog
    SIPA1, signal-induced proliferation-associated 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIPA1, signal-induced proliferation-associated 1
  • Synonyms
    SPA1
  • Links
    NCBI Gene ID: 6494
    neXtProt AC: NX_Q96FS4
    UniProt: Q96FS4

  • Chr Location
    11q13.1; chr11:65638101-65650918 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sipa1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display chronic myelocytic leukemia in either the chronic phase or blast crisis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    11
  • cDNA Data
    75
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056917 Ensembl Gene Model | MGI Sequence Detail 12523 C57BL/6J ±  kb
    transcript ENSMUST00000164304 Ensembl | MGI Sequence Detail 3584 Not Applicable  
    polypeptide ENSMUSP00000128208 Ensembl | MGI Sequence Detail 1038 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 9
      cDNA 75

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36148
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:35455 Hattori M, et al., Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol Cell Biol. 1995 Jan;15(1):552-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory