Npat MGI Mouse Gene Detail - MGI:107605 - nuclear protein in the AT region

Symbol

Npat
Name

nuclear protein in the AT region

Feature Type

protein coding gene
IDs

MGI:107605
NCBI Gene: 244879
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:53448347-53485642 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 29.12 cM
Mapping Data

2 experiments

SNPs within 2kb

812 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107605	protein coding gene	Chr9:53448347-53486867 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034812	protein coding gene	Chr9:52561471-52600290 (+)
A/J	MGP_AJ_G0034793	protein coding gene	Chr9:50909689-50947815 (+)
AKR/J	MGP_AKRJ_G0034721	protein coding gene	Chr9:52007919-52048682 (+)
BALB/cJ	MGP_BALBcJ_G0034785	protein coding gene	Chr9:50658613-50696411 (+)
C3H/HeJ	MGP_C3HHeJ_G0034495	protein coding gene	Chr9:52493616-52531266 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035304	protein coding gene	Chr9:54044071-54083341 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032217	protein coding gene	Chr9:50320607-50357474 (+)
CAST/EiJ	MGP_CASTEiJ_G0033817	protein coding gene	Chr9:52489405-52532719 (+)
CBA/J	MGP_CBAJ_G0034466	protein coding gene	Chr9:55874292-55917952 (+)
DBA/2J	MGP_DBA2J_G0034625	protein coding gene	Chr9:50789230-50826468 (+)
FVB/NJ	MGP_FVBNJ_G0034567	protein coding gene	Chr9:49969382-50006850 (+)
LP/J	MGP_LPJ_G0034707	protein coding gene	Chr9:52867102-52905451 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034610	protein coding gene	Chr9:57460664-57507837 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035326	protein coding gene	Chr9:52016904-52055967 (+)
PWK/PhJ	MGP_PWKPhJ_G0033521	protein coding gene	Chr9:50765804-50804664 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033357	protein coding gene	Chr9:52308956-52352634 (+)
WSB/EiJ	MGP_WSBEiJ_G0033929	protein coding gene	Chr9:52013311-52051438 (+)

Human Ortholog

NPAT, nuclear protein, coactivator of histone transcription

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NPAT, nuclear protein, coactivator of histone transcription
Synonyms

E14, E14/NPAT, p220
Links

HGNC:7896

NCBI Gene ID: 4863

neXtProt AC: NX_Q14207

UniProt: Q14207
Chr Location

11q22.3; chr11:108157215-108222638 (-) GRCh38

MGI Vertebrate Homology

Npat stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NPAT
Gene Tree

Npat

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Phenotype Summary

32 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

9
Targeted

4
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null embryos fail to proceed from the morula to blastocyst stage and have an uncompacted appearance.

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All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

3
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase npat

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All Sequences

42
RefSeq

8
UniProt

1
CCDS

CCDS40637.1

Ensembl

ENSMUSG00000033054 (Evidence)
NCBI Gene

244879

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033054	Ensembl Gene Model \| MGI Sequence Detail	37296	C57BL/6J	± kb
transcript	ENSMUST00000035850	Ensembl \| MGI Sequence Detail	6062	Not Applicable
polypeptide	ENSMUSP00000048709	Ensembl \| MGI Sequence Detail	1420	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011353 protein NPAT

(term hierarchy)
InterPro Domains

IPR006594 LIS1 homology motif

IPR052850 NPAT LisH domain-containing protein

IPR031442 Protein NPAT, C-terminal domain

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All nucleic 11

cDNA 11

Microarray probesets 4

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MGD-MRK-36179, MGI:2143040, MGI:2143360

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 17
Earliest

J:33856 Matsuda Y, et al., Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster. Genomics. 1996 Jun 15;34(3):347-52
Latest

J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75

TSS for Npat:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85139	Chr9:53448321-53448374 (+)	1 bp
Tssr85140	Chr9:53448383-53448394 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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