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Usp39 Gene Detail
Summary
  • Symbol
    Usp39
  • Name
    ubiquitin specific peptidase 39
  • Synonyms
    CGI-21, D6Wsu157e, SAD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107622
    NCBI Gene: 28035
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72295749-72322190 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.27 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107622
 protein coding gene Chr6:72295661-72322190 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030870
 protein coding gene Chr6:72865828-72892678 (-)
A/J MGP_AJ_G0030840
 protein coding gene Chr6:70039234-70067259 (-)
AKR/J MGP_AKRJ_G0030769
 protein coding gene Chr6:72096221-72129849 (-)
BALB/cJ MGP_BALBcJ_G0030851
 protein coding gene Chr6:70069717-70095933 (-)
C3H/HeJ MGP_C3HHeJ_G0030861
 protein coding gene Chr6:112112478-112138956 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031309
 protein coding gene Chr6:74778980-74806510 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028498
 protein coding gene Chr6:69186458-69212564 (-)
CAST/EiJ MGP_CASTEiJ_G0029959
 protein coding gene Chr6:71962832-71989882 (-)
CBA/J MGP_CBAJ_G0030538
 protein coding gene Chr6:77823577-77856922 (-)
DBA/2J MGP_DBA2J_G0030690
 protein coding gene Chr6:69436240-69462735 (-)
FVB/NJ MGP_FVBNJ_G0030643
 protein coding gene Chr6:68817188-68844245 (-)
LP/J MGP_LPJ_G0030769
 protein coding gene Chr6:72770594-72799643 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030678
 protein coding gene Chr6:81216404-81244334 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031335
 protein coding gene Chr6:71909944-71942157 (-)
PWK/PhJ MGP_PWKPhJ_G0029675
 protein coding gene Chr6:68339070-68367799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029503
 protein coding gene Chr6:70642575-70670277 (-)
WSB/EiJ MGP_WSBEiJ_G0030041
 protein coding gene Chr6:72277139-72305047 (-)



Homology
more
  • Human Ortholog
    USP39, ubiquitin specific peptidase 39
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP39, ubiquitin specific peptidase 39
  • Synonyms
    65K, CGI-21, HSPC332, SAD1, SNRNP65
  • Links
    NCBI Gene ID: 10713
    neXtProt AC: NX_Q53GS9
    UniProt: Q53GS9

  • Chr Location
    2p11.2; chr2:85602856-85649283 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit failure of primitive streak formation and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    36
  • cDNA Data
    94
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28035 NCBI Gene Model | MGI Sequence Detail 26442 C57BL/6J ±  kb
    transcript NM_138592 RefSeq | MGI Sequence Detail 2132 C57BL/6  
    polypeptide Q3TIX9 UniProt | EBI | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 94
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36196, MGI:2141363, MGI:2141516
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:44486 Lesh JS, et al., Mapping of the mouse corticotropin-releasing hormone receptor 2 gene (Crhr2) to chromosome 6. Mamm Genome. 1997 Dec;8(12):944-5
    • Latest
      J:354873 Ding R, et al., Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells. Immunity. 2024 Mar 12;57(3):528-540.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory