Larp7 MGI Mouse Gene Detail - MGI:107634 - La ribonucleoprotein 7, transcriptional regulator

Symbol

Larp7
Name

La ribonucleoprotein 7, transcriptional regulator
Synonyms

C330027G06Rik, D3Wsu161e

Feature Type

protein coding gene
IDs

MGI:107634
NCBI Gene: 28036
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:127330363-127346998 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 56.54 cM, cytoband H1
Mapping Data

4 experiments

SNPs within 2kb

466 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107634	protein coding gene	Chr3:127330363-127346998 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027860	protein coding gene	Chr3:130026081-130045898 (-)
A/J	MGP_AJ_G0027819	protein coding gene	Chr3:125578346-125595659 (-)
AKR/J	MGP_AKRJ_G0027784	protein coding gene	Chr3:128825229-128842476 (-)
BALB/cJ	MGP_BALBcJ_G0027831	protein coding gene	Chr3:125439087-125457471 (-)
C3H/HeJ	MGP_C3HHeJ_G0027561	protein coding gene	Chr3:129205030-129221233 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028276	protein coding gene	Chr3:134719060-134743561 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025613	protein coding gene	Chr3:120831482-120847223 (-)
CAST/EiJ	MGP_CASTEiJ_G0027017	protein coding gene	Chr3:128749788-128770107 (-)
CBA/J	MGP_CBAJ_G0027536	protein coding gene	Chr3:139276267-139297690 (-)
DBA/2J	MGP_DBA2J_G0027677	protein coding gene	Chr3:124799167-124816437 (-)
FVB/NJ	MGP_FVBNJ_G0027645	protein coding gene	Chr3:122363891-122380826 (-)
LP/J	MGP_LPJ_G0027787	protein coding gene	Chr3:131577291-131595434 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027675	protein coding gene	Chr3:147198061-147216617 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028332	protein coding gene	Chr3:128460865-128478578 (-)
PWK/PhJ	MGP_PWKPhJ_G0026742	protein coding gene	Chr3:124518610-124537284 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026566	protein coding gene	Chr3:126544311-126563694 (-)
WSB/EiJ	MGP_WSBEiJ_G0027096	protein coding gene	Chr3:129178629-129198002 (-)

Human Ortholog

LARP7, La ribonucleoprotein 7, transcriptional regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LARP7, La ribonucleoprotein 7, transcriptional regulator
Synonyms

ALAZS, HDCMA18P, hLARP7, PIP7S
Links

HGNC:24912

NCBI Gene ID: 51574

neXtProt AC: NX_Q4G0J3

UniProt: Q4G0J3
Chr Location

4q25; chr4:112637077-112657696 (+) GRCh38

MGI Vertebrate Homology

Larp7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LARP7
Gene Tree

Larp7

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

25
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Larp7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available

Mice homozygous for a null mutation display complete perinatal lethality and a decrease in primordial germ cell number and proliferation.

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

40
cDNA Data

22
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase larp7

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All Sequences

52
RefSeq

2
UniProt

3
CCDS

CCDS38626.1

Ensembl

ENSMUSG00000027968 (Evidence)
NCBI Gene

28036

			Length	Strain/Species	Flank
genomic	28036	NCBI Gene Model \| MGI Sequence Detail	16636	C57BL/6J	± kb
transcript	NM_138593	RefSeq \| MGI Sequence Detail	2135	ZRU/MplStud
polypeptide	Q05CL8	UniProt \| EBI \| MGI Sequence Detail	570	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009673 La-related protein 7

(term hierarchy)
InterPro Domains

IPR045180 La domain containing protein

IPR014886 La protein, xRRM domain

IPR034946 La-related protein 7, La domain

IPR034887 LARP7, RNA recognition motif 1

IPR034910 LARP7, RNA recognition motif 2

IPR006630 La-type HTH domain

IPR002344 Lupus La protein

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q05CL8 1 site, 1 O-linked glycan (1 site)

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All nucleic 27

cDNA 22

Primer pair 4

Other 1

Microarray probesets 5

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MGD-MRK-36208, MGI:1915530

Summaries

All 57

Developmental Gene Expression 14

Diseases 1

Gene Ontology 7

Phenotypes 20
Earliest

J:34518 Kerr SM, et al., Ott, a mouse X-linked multigene family expressed specifically during meiosis. Hum Mol Genet. 1996 Aug;5(8):1139-48
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Larp7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35585	Chr3:127346882-127347013 (-)	50 bp
Tssr35584	Chr3:127346859-127346874 (-)	131 bp
Tssr35583	Chr3:127346668-127346682 (-)	323 bp
Tssr35582	Chr3:127335130-127335144 (-)	11,861 bp
Tssr35581	Chr3:127335073-127335113 (-)	11,905 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24