About   Help   FAQ
Ifnb1 Gene Detail
Summary
  • Symbol
    Ifnb1
  • Name
    interferon beta 1, fibroblast
  • Synonyms
    Ifb, IFNB, IFN-beta, interferon beta 1, fibroblast
  • Feature Type
    protein coding gene
  • IDs
    MGI:107657
    NCBI Gene: 15977
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:88440262-88441011 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 41.91 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107657
 protein coding gene Chr4:88440253-88441083 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028421
 protein coding gene Chr4:88400425-88401174 (-)
A/J MGP_AJ_G0028382
 protein coding gene Chr4:85310572-85311321 (-)
AKR/J MGP_AKRJ_G0028331
 protein coding gene Chr4:87421813-87422562 (-)
BALB/cJ MGP_BALBcJ_G0028402
 protein coding gene Chr4:85521982-85522731 (-)
C3H/HeJ MGP_C3HHeJ_G0028117
 protein coding gene Chr4:88136827-88137576 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028841
 protein coding gene Chr4:91769660-91770409 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026141
 protein coding gene Chr4:81295319-81296070 (-)
CAST/EiJ MGP_CASTEiJ_G0027558
 protein coding gene Chr4:85977828-85978577 (-)
CBA/J MGP_CBAJ_G0028086
 protein coding gene Chr4:94596465-94597214 (-)
DBA/2J MGP_DBA2J_G0028235
 protein coding gene Chr4:85068871-85069620 (-)
FVB/NJ MGP_FVBNJ_G0028201
 protein coding gene Chr4:84023757-84024506 (-)
LP/J MGP_LPJ_G0028335
 protein coding gene Chr4:88745123-88745872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028230
 protein coding gene Chr4:99590396-99591145 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028878
 protein coding gene Chr4:87556569-87557318 (-)
PWK/PhJ MGP_PWKPhJ_G0027281
 protein coding gene Chr4:83390028-83390777 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027106
 protein coding gene Chr4:85052506-85053255 (-)
WSB/EiJ MGP_WSBEiJ_G0027634
 protein coding gene Chr4:87762499-87763248 (-)



Homology
more
  • Human Ortholog
    IFNB1, interferon beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNB1, interferon beta 1
  • Synonyms
    IFB, IFF, IFNB, IFN-beta
  • Links
    NCBI Gene ID: 3456
    neXtProt AC: NX_P01574
    UniProt: P01574

  • Chr Location
    9p21.3; chr9:21077104-21077942 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IFNB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 6 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    126 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit enhanced proliferation and reduced TNF-alpha production by activated T lymphocytes, a defect in B cell maturation, fewer circulating granulocytes and macrophages, and increased viral susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    6
  • cDNA Data
    7
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048806 Ensembl Gene Model | MGI Sequence Detail 750 C57BL/6J ±  kb
    transcript ENSMUST00000055671 Ensembl | MGI Sequence Detail 750 Not Applicable  
    polypeptide ENSMUSP00000056720 Ensembl | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 8
      Primer pair 4
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11212, MGD-MRK-36232
    References
    more
    • Summaries
      All 354
      Developmental Gene Expression 15
      Gene Ontology 16
      Phenotypes 126
    • Earliest
      J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
    • Latest
      J:359208 Ashby KM, et al., Sterile production of interferons in the thymus affects T cell repertoire selection. Sci Immunol. 2024 Jul 26;9(97):eadp1139
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory