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Ifnar1 Gene Detail
Summary
  • Symbol
    Ifnar1
  • Name
    interferon (alpha and beta) receptor 1
  • Synonyms
    Ifar, IFN-alpha/betaR, Ifrc
  • Feature Type
    protein coding gene
  • IDs
    MGI:107658
    NCBI Gene: 15975
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91282126-91304329 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 52.98 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107658
 protein coding gene Chr16:91281016-91307411 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023041
 protein coding gene Chr16:92495892-92518051 (+)
A/J MGP_AJ_G0023009
 protein coding gene Chr16:88179235-88201613 (+)
AKR/J MGP_AKRJ_G0022979
 protein coding gene Chr16:90832309-90857183 (+)
BALB/cJ MGP_BALBcJ_G0023011
 protein coding gene Chr16:88702612-88725846 (+)
C3H/HeJ MGP_C3HHeJ_G0022772
 protein coding gene Chr16:91413483-91436907 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023458
 protein coding gene Chr16:95493907-95515401 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020960
 protein coding gene Chr16:85873776-85892556 (+)
CAST/EiJ MGP_CASTEiJ_G0022291
 protein coding gene Chr16:91969988-91994173 (+)
CBA/J MGP_CBAJ_G0022741
 protein coding gene Chr16:99564437-99592463 (+)
DBA/2J MGP_DBA2J_G0022875
 protein coding gene Chr16:88075311-88097816 (+)
FVB/NJ MGP_FVBNJ_G0022849
 protein coding gene Chr16:87205605-87227415 (+)
LP/J MGP_LPJ_G0022945
 protein coding gene Chr16:92207876-92230495 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022870
 protein coding gene Chr16:104121606-104144280 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023476
 protein coding gene Chr16:91356816-91379613 (+)
PWK/PhJ MGP_PWKPhJ_G0022036
 protein coding gene Chr16:88251647-88274215 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021866
 protein coding gene Chr16:90898557-90924053 (+)
WSB/EiJ MGP_WSBEiJ_G0022343
 protein coding gene Chr16:91597180-91619862 (+)



Homology
more
  • Human Ortholog
    IFNAR1, interferon alpha and beta receptor subunit 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNAR1, interferon alpha and beta receptor subunit 1
  • Synonyms
    AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, IMD106
  • Links
    NCBI Gene ID: 3454
    neXtProt AC: NX_P17181
    UniProt: P17181

  • Chr Location
    21q22.11; chr21:33324387-33359864 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IFNAR1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 5 alleles in 10 genetic backgrounds
    67 phenotypes from multigenic genotypes
    1485 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1070
  • Tissues
    201
  • cDNA Data
    101
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022967 Ensembl Gene Model | MGI Sequence Detail 22204 C57BL/6J ±  kb
    transcript ENSMUST00000023689 Ensembl | MGI Sequence Detail 3909 Not Applicable  
    polypeptide ENSMUSP00000023689 Ensembl | MGI Sequence Detail 590 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 2
      cDNA 101
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11211, MGD-MRK-11223, MGD-MRK-36233
    References
    more
    • Summaries
      All 1654
      Developmental Gene Expression 9
      Diseases 7
      Gene Ontology 15
      Phenotypes 1485
    • Earliest
      J:6319 Cox DR, et al., Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2168-72
    • Latest
      J:359554 Li N, et al., Redundancy in Innate Immune Pathways That Promote CD8(+) T-Cell Responses in AAV1 Muscle Gene Transfer. Viruses. 2024 Sep 24;16(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory