Gpm6b MGI Mouse Gene Detail - MGI:107672

Symbol

Gpm6b
Name

glycoprotein m6b
Synonyms

Gpm6, M6B

Feature Type

protein coding gene
IDs

MGI:107672
NCBI Gene: 14758
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

ChrX:165021907-165171984 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 76.86 cM
Mapping Data

2 experiments

SNPs within 2kb

2874 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107672	protein coding gene	ChrX:165021907-165172028 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036264	protein coding gene	ChrX:164370034-164520156 (+)
A/J	MGP_AJ_G0036232	protein coding gene	ChrX:163505737-163660933 (+)
AKR/J	MGP_AKRJ_G0036162	protein coding gene	ChrX:168769306-168920684 (+)
BALB/cJ	MGP_BALBcJ_G0036227	protein coding gene	ChrX:161498753-161649134 (+)
C3H/HeJ	MGP_C3HHeJ_G0035934	protein coding gene	ChrX:164684846-164835264 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036750	protein coding gene	ChrX:169167953-169315891 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033570	protein coding gene	ChrX:154387960-154536895 (+)
CAST/EiJ	MGP_CASTEiJ_G0035221	protein coding gene	ChrX:143556172-143716158 (+)
CBA/J	MGP_CBAJ_G0035908	protein coding gene	ChrX:174100356-174255238 (+)
DBA/2J	MGP_DBA2J_G0036074	protein coding gene	ChrX:162352242-162502959 (+)
FVB/NJ	MGP_FVBNJ_G0036006	protein coding gene	ChrX:161473100-161622206 (+)
LP/J	MGP_LPJ_G0036159	protein coding gene	ChrX:165476014-165637827 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0036038	protein coding gene	ChrX:182818036-182976947 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036789	protein coding gene	ChrX:163846940-163997782 (+)
PWK/PhJ	MGP_PWKPhJ_G0034920	protein coding gene	ChrX:140321694-140473496 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034740	protein coding gene	ChrX:144077174-144238496 (+)
WSB/EiJ	MGP_WSBEiJ_G0035357	protein coding gene	ChrX:161685642-161838733 (+)

Human Ortholog

GPM6B, glycoprotein M6B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPM6B, glycoprotein M6B
Synonyms

M6B
Links

HGNC:4461

NCBI Gene ID: 2824

neXtProt AC: NX_Q13491

UniProt: Q13491
Chr Location

Xp22.2; chrX:13770939-13938638 (-) GRCh38

MGI Vertebrate Homology

Gpm6b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPM6B
Gene Tree

Gpm6b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
30 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

6 strains or lines available

Mice null for this gene display axon-myelin interface irregularities but do not show motor function defects.

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

117
cDNA Data

133
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpm6b

ZFIN gpm6ba, gpm6bb

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All Sequences

108
RefSeq

32
UniProt

6
CCDS

CCDS30526.1, CCDS53243.1, CCDS53244.1, CCDS53245.1, CCDS53246.1, CCDS53247.1

Ensembl

ENSMUSG00000031342 (Evidence)
NCBI Gene

14758

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031342	Ensembl Gene Model \| MGI Sequence Detail	150078	C57BL/6J	± kb
transcript	ENSMUST00000112229	Ensembl \| MGI Sequence Detail	3203	Not Applicable
polypeptide	ENSMUSP00000107848	Ensembl \| MGI Sequence Detail	328	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008179 neuronal membrane glycoprotein M6-b

(term hierarchy)
InterPro Domains

IPR001614 Myelin proteolipid protein PLP

IPR018237 Myelin proteolipid protein PLP, conserved site
GlyGen

P35803 3 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 138

cDNA 135

Primer pair 2

Other 1

Microarray probesets 6

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MGD-MRK-33055, MGD-MRK-36247, MGI:2147902

Summaries

All 52

Developmental Gene Expression 14

Gene Ontology 5

Phenotypes 9
Earliest

J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Gpm6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162670	ChrX:165021764-165021778 (+)	-136 bp
Tssr162671	ChrX:165021780-165021791 (+)	-121 bp
Tssr162672	ChrX:165021793-165021807 (+)	-107 bp
Tssr162673	ChrX:165021897-165021910 (+)	-3 bp
Tssr162674	ChrX:165021919-165022020 (+)	63 bp
Tssr162675	ChrX:165022022-165022050 (+)	129 bp
Tssr162676	ChrX:165127754-165127766 (+)	105,853 bp
Tssr162677	ChrX:165127780-165127910 (+)	105,938 bp
Tssr162678	ChrX:165127988-165128027 (+)	106,101 bp
Tssr162679	ChrX:165129605-165129608 (+)	107,700 bp
Tssr162680	ChrX:165140650-165140654 (+)	118,745 bp
Tssr162681	ChrX:165155662-165155673 (+)	133,761 bp
Tssr162682	ChrX:165169575-165169589 (+)	147,675 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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