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Tank Gene Detail
Summary
  • Symbol
    Tank
  • Name
    TRAF family member-associated Nf-kappa B activator
  • Synonyms
    E430026L09Rik, I-TRAF
  • Feature Type
    protein coding gene
  • IDs
    MGI:107676
    NCBI Gene: 21353
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:61408929-61484515 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 35.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1570 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107676
 protein coding gene Chr2:61408901-61484515 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025765
 protein coding gene Chr2:61241551-61319924 (+)
A/J MGP_AJ_G0025741
 protein coding gene Chr2:58890159-58966074 (+)
AKR/J MGP_AKRJ_G0025711
 protein coding gene Chr2:60476399-60555486 (+)
BALB/cJ MGP_BALBcJ_G0025736
 protein coding gene Chr2:58994055-59070030 (+)
C3H/HeJ MGP_C3HHeJ_G0025497
 protein coding gene Chr2:60582454-60656889 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026183
 protein coding gene Chr2:63036659-63116077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023587
 protein coding gene Chr2:56395473-56469077 (+)
CAST/EiJ MGP_CASTEiJ_G0024961
 protein coding gene Chr2:60646804-60729868 (+)
CBA/J MGP_CBAJ_G0025477
 protein coding gene Chr2:65421830-65497199 (+)
DBA/2J MGP_DBA2J_G0025608
 protein coding gene Chr2:58457347-58538704 (+)
FVB/NJ MGP_FVBNJ_G0025570
 protein coding gene Chr2:57996850-58072051 (+)
LP/J MGP_LPJ_G0025696
 protein coding gene Chr2:61068577-61146530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025601
 protein coding gene Chr2:67012013-67107776 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026240
 protein coding gene Chr2:60522734-60599553 (+)
PWK/PhJ MGP_PWKPhJ_G0024702
 protein coding gene Chr2:58328772-58415284 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024509
 protein coding gene Chr2:60647391-60731245 (+)
WSB/EiJ MGP_WSBEiJ_G0025029
 protein coding gene Chr2:60844929-60924742 (+)



Homology
more
  • Human Ortholog
    TANK, TRAF family member associated NFKB activator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TANK, TRAF family member associated NFKB activator
  • Synonyms
    I-TRAF, ITRAF, TRAF2
  • Links
    NCBI Gene ID: 10010
    neXtProt AC: NX_Q92844
    UniProt: Q92844

  • Chr Location
    2q24.2; chr2:161136908-161236230 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop fatal glomerulonephritis owing to deposition of immune complexes. Dendritic cells, macrophages and B cells from these mice are hyper-responsive to stimuli leading to increased production of immunoglobulins and inflammatory cytokines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    50
  • cDNA Data
    67
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064289 Ensembl Gene Model | MGI Sequence Detail 75587 C57BL/6J ±  kb
    transcript ENSMUST00000078074 Ensembl | MGI Sequence Detail 2018 Not Applicable  
    polypeptide ENSMUSP00000077219 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003146 TRAF family member-associated NF-kappa-B activator
      (term hierarchy)
    • InterPro Domains
      IPR041641 CALCOCO1/2, zinc finger UBZ1-type
      IPR024581 Tbk1/Ikki binding domain
      IPR039669 TRAF family member-associated NF-kappa-B activator
    • GlyGen
      P70347 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 67
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36251, MGI:2139525, MGI:2443907
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:34830 Rothe M, et al., I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8241-6
    • Latest
      J:320014 Wakabayashi A, et al., TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation. Life Sci Alliance. 2022 Feb;5(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory