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Slc5a1 Gene Detail
Summary
  • Symbol
    Slc5a1
  • Name
    solute carrier family 5 (sodium/glucose cotransporter), member 1
  • Synonyms
    Sglt1, sodium glucose cotransporter 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107678
    NCBI Gene: 20537
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33261563-33320043 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.46 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107678
 protein coding gene Chr5:33261563-33320214 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029441
 protein coding gene Chr5:31267056-31330178 (+)
A/J MGP_AJ_G0029408
 protein coding gene Chr5:30249737-30308752 (+)
AKR/J MGP_AKRJ_G0029357
 protein coding gene Chr5:31424422-31490120 (+)
BALB/cJ MGP_BALBcJ_G0029418
 protein coding gene Chr5:30775017-30835339 (+)
C3H/HeJ MGP_C3HHeJ_G0029140
 protein coding gene Chr5:31456709-31518812 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029872
 protein coding gene Chr5:33147533-33213113 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027109
 protein coding gene Chr5:28050596-28128694 (+)
CAST/EiJ MGP_CASTEiJ_G0028549
 protein coding gene Chr5:30534538-30600994 (+)
CBA/J MGP_CBAJ_G0029108
 protein coding gene Chr5:33833881-33899387 (+)
DBA/2J MGP_DBA2J_G0029256
 protein coding gene Chr5:30431890-30491322 (+)
FVB/NJ MGP_FVBNJ_G0029215
 protein coding gene Chr5:29848615-29908073 (+)
LP/J MGP_LPJ_G0029341
 protein coding gene Chr5:31690484-31748022 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029245
 protein coding gene Chr5:34688068-34757804 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029905
 protein coding gene Chr5:30939675-31002173 (+)
PWK/PhJ MGP_PWKPhJ_G0028274
 protein coding gene Chr5:29555904-29615662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028105
 protein coding gene Chr5:30375769-30444000 (+)
WSB/EiJ MGP_WSBEiJ_G0028630
 protein coding gene Chr5:30992176-31054604 (+)



Homology
more
  • Human Ortholog
    SLC5A1, solute carrier family 5 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC5A1, solute carrier family 5 member 1
  • Synonyms
    D22S675, NAGT, SGLT-1, SGLT1
  • Links
    NCBI Gene ID: 6523
    neXtProt AC: NX_P13866
    UniProt: P13866

  • Chr Location
    22q12.3; chr22:32043261-32113029 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC5A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality unless maintained on a glucose-galatose-free diet, distended intestine, impaired glucose transport across the brush border membrane and impaired renal glucose reabsorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    950
  • Tissues
    183
  • cDNA Data
    33
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20537 NCBI Gene Model | MGI Sequence Detail 58481 C57BL/6J ±  kb
    transcript NM_019810 RefSeq | MGI Sequence Detail 3933 C57BL/6  
    polypeptide Q8C3K6 UniProt | EBI | MGI Sequence Detail 665 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36253
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 11
      Phenotypes 44
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:336392 Johnston SN, et al., GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc. JCI Insight. 2023 Apr 24;8(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory