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Plxna3 Gene Detail
Summary
  • Symbol
    Plxna3
  • Name
    plexin A3
  • Synonyms
    PlexA3, Plxa3, Plxn3, Plxn4, SEX
  • Feature Type
    protein coding gene
  • IDs
    MGI:107683
    NCBI Gene: 18846
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73372672-73388295 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.00 cM, cytoband B-C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107683
 protein coding gene ChrX:73372644-73388295 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035842
 protein coding gene ChrX:70131616-70147236 (+)
A/J MGP_AJ_G0035823
 protein coding gene ChrX:70313262-70328882 (+)
AKR/J MGP_AKRJ_G0035748
 protein coding gene ChrX:72215086-72230792 (+)
BALB/cJ MGP_BALBcJ_G0035808
 protein coding gene ChrX:69340287-69355909 (+)
C3H/HeJ MGP_C3HHeJ_G0035513
 protein coding gene ChrX:70604183-70619798 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036338
 protein coding gene ChrX:72292147-72307766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033182
 protein coding gene ChrX:69379596-69395235 (+)
CAST/EiJ MGP_CASTEiJ_G0034804
 protein coding gene ChrX:55985885-56001526 (+)
CBA/J MGP_CBAJ_G0035488
 protein coding gene ChrX:74289273-74304889 (+)
DBA/2J MGP_DBA2J_G0035645
 protein coding gene ChrX:69773142-69788756 (+)
FVB/NJ MGP_FVBNJ_G0035589
 protein coding gene ChrX:69117256-69132880 (+)
LP/J MGP_LPJ_G0035730
 protein coding gene ChrX:70907833-70923456 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035627
 protein coding gene ChrX:76850806-76866412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036360
 protein coding gene ChrX:69946801-69962420 (+)
PWK/PhJ MGP_PWKPhJ_G0034503
 protein coding gene ChrX:53945959-53961565 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034337
 protein coding gene ChrX:56852712-56868335 (+)
WSB/EiJ MGP_WSBEiJ_G0034945
 protein coding gene ChrX:69230669-69246288 (+)



Homology
more
  • Human Ortholog
    PLXNA3, plexin A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNA3, plexin A3
  • Synonyms
    6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
  • Links
    NCBI Gene ID: 55558
    neXtProt AC: NX_P51805
    UniProt: P51805

  • Chr Location
    Xq28
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene possess misdirected axons in the hippocampus. They are, otherwise, indistinguishable from wild-type mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1224
  • Tissues
    366
  • cDNA Data
    81
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031398 Ensembl Gene Model | MGI Sequence Detail 15624 C57BL/6J ±  kb
    transcript ENSMUST00000004326 Ensembl | MGI Sequence Detail 6943 Not Applicable  
    polypeptide ENSMUSP00000004326 Ensembl | MGI Sequence Detail 1872 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 1
      cDNA 84
      Primer pair 4
      Other 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36258, MGD-MRK-39626, MGI:109627
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 50
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:26634 Rivella S, et al., A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995 Aug 10;28(3):377-82
    • Latest
      J:334607 Bsharat S, et al., MafB-dependent neurotransmitter signaling promotes beta cell migration in the developing pancreas. Development. 2023 Mar 15;150(6):dev201009
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory