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Plxna1 Gene Detail
Summary
  • Symbol
    Plxna1
  • Name
    plexin A1
  • Synonyms
    2600013D04Rik, NOV, PlexA1, Plxn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107685
    NCBI Gene: 18844
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:89293295-89339595 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    811 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107685
 protein coding gene Chr6:89293295-89339602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031019
 protein coding gene Chr6:90767259-90808790 (-)
A/J MGP_AJ_G0030985
 protein coding gene Chr6:87311886-87358264 (-)
AKR/J MGP_AKRJ_G0030916
 protein coding gene Chr6:89778487-89824772 (-)
BALB/cJ MGP_BALBcJ_G0030998
 protein coding gene Chr6:87285358-87326753 (-)
C3H/HeJ MGP_C3HHeJ_G0030712
 protein coding gene Chr6:94623703-94670057 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031455
 protein coding gene Chr6:93206861-93253167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028636
 protein coding gene Chr6:85380115-85426150 (-)
CAST/EiJ MGP_CASTEiJ_G0030107
 protein coding gene Chr6:89886086-89932301 (-)
CBA/J MGP_CBAJ_G0030682
 protein coding gene Chr6:96707839-96749370 (-)
DBA/2J MGP_DBA2J_G0030838
 protein coding gene Chr6:86549413-86590944 (-)
FVB/NJ MGP_FVBNJ_G0030791
 protein coding gene Chr6:85751765-85798188 (-)
LP/J MGP_LPJ_G0030915
 protein coding gene Chr6:90796632-90839469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030824
 protein coding gene Chr6:100850338-100896775 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031482
 protein coding gene Chr6:89625366-89671798 (-)
PWK/PhJ MGP_PWKPhJ_G0029822
 protein coding gene Chr6:85525316-85571596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029650
 protein coding gene Chr6:88460609-88506931 (-)
WSB/EiJ MGP_WSBEiJ_G0030188
 protein coding gene Chr6:90073721-90115086 (-)



Homology
more
  • Human Ortholog
    PLXNA1, plexin A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNA1, plexin A1
  • Synonyms
    DWOPNED, NOV, NOVP, PLEXIN-A1, PLXN1
  • Links
    NCBI Gene ID: 5361
    neXtProt AC: NX_Q9UIW2
    UniProt: Q9UIW2

  • Chr Location
    3q21.3; chr3:126982693-127037389 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit bone cellularity abnormalities, altered dendritic cell physiology, abnormal proprioceptive and oligodendrocyte morphology, and increased lymphatic branching complexity and LEC numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1074
  • Tissues
    273
  • cDNA Data
    204
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18844 NCBI Gene Model | MGI Sequence Detail 46301 C57BL/6J ±  kb
    transcript NM_008881 RefSeq | MGI Sequence Detail 9045 C57BL/6  
    polypeptide P70206 UniProt | EBI | MGI Sequence Detail 1894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 215
      cDNA 206
      Primer pair 2
      Other 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36260, MGI:1917296
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 66
      Gene Ontology 15
      Phenotypes 38
    • Earliest
      J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
    • Latest
      J:350995 Thowfeequ S, et al., An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration. Dev Cell. 2024 Jun 2;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory