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Zfp462 Gene Detail
Summary
  • Symbol
    Zfp462
  • Name
    zinc finger protein 462
  • Synonyms
    9430078C22Rik, Gt4-2, Zfpip
  • Feature Type
    protein coding gene
  • IDs
    MGI:107690
    NCBI Gene: 242466
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:54945048-55083563 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 29.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2982 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107690
 protein coding gene Chr4:54942038-55083563 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028304
 protein coding gene Chr4:53637531-53781036 (+)
A/J MGP_AJ_G0028265
 protein coding gene Chr4:51563543-51705564 (+)
AKR/J MGP_AKRJ_G0028214
 protein coding gene Chr4:52979941-53121612 (+)
BALB/cJ MGP_BALBcJ_G0028284
 protein coding gene Chr4:51733865-51876088 (+)
C3H/HeJ MGP_C3HHeJ_G0028005
 protein coding gene Chr4:53496367-53640798 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028725
 protein coding gene Chr4:55552320-55692541 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026033
 protein coding gene Chr4:48448364-48587079 (+)
CAST/EiJ MGP_CASTEiJ_G0027443
 protein coding gene Chr4:53176254-53322355 (+)
CBA/J MGP_CBAJ_G0027970
 protein coding gene Chr4:57461914-57611937 (+)
DBA/2J MGP_DBA2J_G0028120
 protein coding gene Chr4:51503469-51644455 (+)
FVB/NJ MGP_FVBNJ_G0028087
 protein coding gene Chr4:50720559-50862183 (+)
LP/J MGP_LPJ_G0028219
 protein coding gene Chr4:53721706-53866840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028111
 protein coding gene Chr4:60682543-60826913 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028761
 protein coding gene Chr4:53189585-53329405 (+)
PWK/PhJ MGP_PWKPhJ_G0027168
 protein coding gene Chr4:51469787-51609806 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026996
 protein coding gene Chr4:52461632-52607680 (+)
WSB/EiJ MGP_WSBEiJ_G0027521
 protein coding gene Chr4:53098832-53242258 (+)



Homology
more
  • Human Ortholog
    ZNF462, zinc finger protein 462
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF462, zinc finger protein 462
  • Synonyms
    WSKA, Zfp462, ZFPIP
  • Links
    NCBI Gene ID: 58499
    neXtProt AC: NX_Q96JM2
    UniProt: Q96JM2

  • Chr Location
    9q31.2; chr9:106860158-107013634 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zfp462 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out allele exhibit complete prenatal lethality with decreased birth body size and eyelids open at birth. Heterozygotes show postnatal growth retardation, low body weight and brain weight, and anxiety-like behaviors with excessive self-grooming and hair loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1194
  • Tissues
    209
  • cDNA Data
    69
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060206 Ensembl Gene Model | MGI Sequence Detail 138516 C57BL/6J ±  kb
    transcript ENSMUST00000098070 Ensembl | MGI Sequence Detail 10465 Not Applicable  
    polypeptide ENSMUSP00000095677 Ensembl | MGI Sequence Detail 2495 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 69
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36266, MGI:2443147
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:1146 Skarnes WC, et al., A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev. 1992 Jun;6(6):903-18
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory