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Dnah12 Gene Detail
Summary
  • Symbol
    Dnah12
  • Name
    dynein, axonemal, heavy chain 12
  • Synonyms
    4921531P07Rik, DHC3, DLP12, Dnahc12, Dnahc7l, Hdhc3, HL-19, HL19, LOC380889
  • Feature Type
    protein coding gene
  • IDs
    MGI:107720
    NCBI Gene: 110083
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:26414429-26613660 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4791 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107720
 protein coding gene Chr14:26412709-26614250 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021085
 protein coding gene Chr14:19674227-19880385 (+)
A/J MGP_AJ_G0021034
 protein coding gene Chr14:18896714-19090178 (+)
AKR/J MGP_AKRJ_G0021011
 protein coding gene Chr14:19930185-20133842 (+)
BALB/cJ MGP_BALBcJ_G0021037
 protein coding gene Chr14:19013071-19205612 (+)
C3H/HeJ MGP_C3HHeJ_G0020821
 protein coding gene Chr14:19795874-19988544 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021470
 protein coding gene Chr14:20495498-20700340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019033
 protein coding gene Chr14:19046165-19238096 (+)
CAST/EiJ MGP_CASTEiJ_G0020345
 protein coding gene Chr14:19400884-19619868 (+)
CBA/J MGP_CBAJ_G0020787
 protein coding gene Chr14:21311916-21529297 (+)
DBA/2J MGP_DBA2J_G0020910
 protein coding gene Chr14:18984744-19180286 (+)
FVB/NJ MGP_FVBNJ_G0020893
 protein coding gene Chr14:18945643-19136018 (+)
LP/J MGP_LPJ_G0020978
 protein coding gene Chr14:19944891-20146128 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020919
 protein coding gene Chr14:20644419-20888222 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021503
 protein coding gene Chr14:19700573-19897964 (+)
PWK/PhJ MGP_PWKPhJ_G0020094
 protein coding gene Chr14:18355691-18576554 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019917
 protein coding gene Chr14:19180415-19387160 (+)
WSB/EiJ MGP_WSBEiJ_G0020401
 protein coding gene Chr14:19735761-19938544 (+)



Homology
more
  • Human Ortholog
    DNAH12, dynein axonemal heavy chain 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAH12, dynein axonemal heavy chain 12
  • Synonyms
    DHC3, DLP12, DLP3, DNAH12L, DNAH7L, DNAHC12, DNAHC3, DNHD2, HDHC3, HL-19, HL19
  • Links
    NCBI Gene ID: 201625
    neXtProt AC: NX_Q6ZR08
    UniProt: Q6ZR08

  • Chr Location
    3p14.3; chr3:57293699-57556034 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    5
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
  • All Sequences
    43
  • RefSeq
    11
  • UniProt
    4
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021879 Ensembl Gene Model | MGI Sequence Detail 199232 C57BL/6J ±  kb
transcript ENSMUST00000022433 Ensembl | MGI Sequence Detail 12009 Not Applicable  
polypeptide ENSMUSP00000022433 Ensembl | MGI Sequence Detail 3960 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006558 dynein axonemal heavy chain 12
    (term hierarchy)
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR026983 Dynein heavy chain
    IPR041589 Dynein heavy chain 3, AAA+ lid domain
    IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
    IPR041466 Dynein heavy chain, AAA 5 extension domain
    IPR041658 Dynein heavy chain AAA lid domain
    IPR042219 Dynein heavy chain AAA lid domain superfamily
    IPR024317 Dynein heavy chain, AAA module D4
    IPR041228 Dynein heavy chain, C-terminal domain
    IPR043160 Dynein heavy chain, C-terminal domain, barrel region
    IPR042222 Dynein heavy chain, domain 2, N-terminal
    IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
    IPR013602 Dynein heavy chain, linker
    IPR042228 Dynein heavy chain, linker, subdomain 3
    IPR004273 Dynein heavy chain region D6 P-loop domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    Q3V0Q1 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36296, MGI:2685130, MGI:2685753
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory