Dnah12 MGI Mouse Gene Detail - MGI:107720 - dynein, axonemal, heavy chain 12

Symbol

Dnah12
Name

dynein, axonemal, heavy chain 12
Synonyms

4921531P07Rik, DHC3, DLP12, Dnahc12, Dnahc7l, Hdhc3, HL-19, HL19, LOC380889

Feature Type

protein coding gene
IDs

MGI:107720
NCBI Gene: 110083
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:26414429-26613660 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 16.09 cM
Mapping Data

2 experiments

SNPs within 2kb

4791 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107720	protein coding gene	Chr14:26412709-26614250 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021085	protein coding gene	Chr14:19674227-19880385 (+)
A/J	MGP_AJ_G0021034	protein coding gene	Chr14:18896714-19090178 (+)
AKR/J	MGP_AKRJ_G0021011	protein coding gene	Chr14:19930185-20133842 (+)
BALB/cJ	MGP_BALBcJ_G0021037	protein coding gene	Chr14:19013071-19205612 (+)
C3H/HeJ	MGP_C3HHeJ_G0020821	protein coding gene	Chr14:19795874-19988544 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021470	protein coding gene	Chr14:20495498-20700340 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019033	protein coding gene	Chr14:19046165-19238096 (+)
CAST/EiJ	MGP_CASTEiJ_G0020345	protein coding gene	Chr14:19400884-19619868 (+)
CBA/J	MGP_CBAJ_G0020787	protein coding gene	Chr14:21311916-21529297 (+)
DBA/2J	MGP_DBA2J_G0020910	protein coding gene	Chr14:18984744-19180286 (+)
FVB/NJ	MGP_FVBNJ_G0020893	protein coding gene	Chr14:18945643-19136018 (+)
LP/J	MGP_LPJ_G0020978	protein coding gene	Chr14:19944891-20146128 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020919	protein coding gene	Chr14:20644419-20888222 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021503	protein coding gene	Chr14:19700573-19897964 (+)
PWK/PhJ	MGP_PWKPhJ_G0020094	protein coding gene	Chr14:18355691-18576554 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019917	protein coding gene	Chr14:19180415-19387160 (+)
WSB/EiJ	MGP_WSBEiJ_G0020401	protein coding gene	Chr14:19735761-19938544 (+)

Human Ortholog

DNAH12, dynein axonemal heavy chain 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAH12, dynein axonemal heavy chain 12
Synonyms

DHC3, DLP12, DLP3, DNAH12L, DNAH7L, DNAHC12, DNAHC3, DNHD2, HDHC3, HL-19, HL19
Links

HGNC:2943

NCBI Gene ID: 201625

neXtProt AC: NX_Q6ZR08

UniProt: Q6ZR08
Chr Location

3p14.3

MGI Vertebrate Homology

Dnah12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAH12
Gene Tree

Dnah12

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

194 strains or lines available

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

5
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnah12

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All Sequences

43
RefSeq

11
UniProt

4

Ensembl

ENSMUSG00000021879 (Evidence)
NCBI Gene

110083

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021879	Ensembl Gene Model \| MGI Sequence Detail	199232	C57BL/6J	± kb
transcript	ENSMUST00000022433	Ensembl \| MGI Sequence Detail	12009	Not Applicable
polypeptide	ENSMUSP00000022433	Ensembl \| MGI Sequence Detail	3960	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006558 dynein axonemal heavy chain 12

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR026983 Dynein heavy chain

IPR041589 Dynein heavy chain 3, AAA+ lid domain

IPR043157 Dynein heavy chain, AAA1 domain, small subdomain

IPR041466 Dynein heavy chain, AAA 5 extension domain

IPR041658 Dynein heavy chain AAA lid domain

IPR042219 Dynein heavy chain AAA lid domain superfamily

IPR024317 Dynein heavy chain, AAA module D4

IPR041228 Dynein heavy chain, C-terminal domain

IPR043160 Dynein heavy chain, C-terminal domain, barrel region

IPR042222 Dynein heavy chain, domain 2, N-terminal

IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region

IPR013602 Dynein heavy chain, linker

IPR042228 Dynein heavy chain, linker, subdomain 3

IPR004273 Dynein heavy chain region D6 P-loop domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q3V0Q1 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 8

cDNA 8

Microarray probesets 4

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MGD-MRK-36296, MGI:2685130, MGI:2685753

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Dnah12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124706	Chr14:26412766-26412791 (+)	-1,650 bp
Tssr124707	Chr14:26412816-26412826 (+)	-1,608 bp
Tssr124708	Chr14:26414409-26414417 (+)	-16 bp
Tssr124709	Chr14:26414422-26414432 (+)	-2 bp
Tssr124710	Chr14:26414440-26414451 (+)	17 bp
Tssr124711	Chr14:26488129-26488159 (+)	73,715 bp
Tssr124712	Chr14:26488281-26488289 (+)	73,856 bp
Tssr124713	Chr14:26488399-26488413 (+)	73,977 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24