Hoxb13 MGI Mouse Gene Detail - MGI:107730

Symbol

Hoxb13
Name

homeobox B13

Feature Type

protein coding gene
IDs

MGI:107730
NCBI Gene: 15408
Member of

Hoxb cluster
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:96085142-96087436 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.63 cM
Mapping Data

4 experiments

SNPs within 2kb

125 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107730	protein coding gene	Chr11:96085142-96088273 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019000	protein coding gene	Chr11:98494302-98497433 (+)
A/J	MGP_AJ_G0018968	protein coding gene	Chr11:94477312-94480444 (+)
AKR/J	MGP_AKRJ_G0018938	protein coding gene	Chr11:97388170-97391302 (+)
BALB/cJ	MGP_BALBcJ_G0018941	protein coding gene	Chr11:94963043-94966174 (+)
C3H/HeJ	MGP_C3HHeJ_G0018755	protein coding gene	Chr11:97528678-97531809 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019393	protein coding gene	Chr11:101582476-101585607 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017023	protein coding gene	Chr11:91964557-91967769 (+)
CAST/EiJ	MGP_CASTEiJ_G0018308	protein coding gene	Chr11:98351616-98354749 (+)
CBA/J	MGP_CBAJ_G0018726	protein coding gene	Chr11:105735824-105738956 (+)
DBA/2J	MGP_DBA2J_G0018834	protein coding gene	Chr11:94046937-94050068 (+)
FVB/NJ	MGP_FVBNJ_G0018823	protein coding gene	Chr11:93522292-93525423 (+)
LP/J	MGP_LPJ_G0018904	protein coding gene	Chr11:99033641-99036772 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018850	protein coding gene	Chr11:105722745-105725876 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019433	protein coding gene	Chr11:97695819-97698950 (+)
PWK/PhJ	MGP_PWKPhJ_G0018080	protein coding gene	Chr11:95001314-95004445 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017869	protein coding gene	Chr11:97423197-97426341 (+)
WSB/EiJ	MGP_WSBEiJ_G0018358	protein coding gene	Chr11:97588958-97592089 (+)

Human Ortholog

HOXB13, homeobox B13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXB13, homeobox B13
Synonyms

HPC9, PSGD
Links

HGNC:5112

NCBI Gene ID: 10481

neXtProt AC: NX_Q92826

UniProt: Q92826
Chr Location

17q21.32; chr17:48724763-48728750 (-) GRCh38

MGI Vertebrate Homology

Hoxb13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOXB13
Gene Tree

Hoxb13

Diseases

2 with human HOXB13 associations

				Human Disease	Mouse Models
				ductal carcinoma in situ IDs ductal carcinoma in situ DOID:0060074
				renal cell carcinoma IDs renal cell carcinoma DOID:4450 EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 UMLS_CUI:C0007134

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 5 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

3
Targeted

10
Genomic Mutations

2 involving Hoxb13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for loss of function mutations show overgrowth in all major structures derived from the tail bud.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

882
Tissues

148
cDNA Data

33
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOXB13

ZFIN hoxb13a

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS25291.1

Ensembl

ENSMUSG00000049604 (Evidence)
NCBI Gene

15408

			Length	Strain/Species	Flank
genomic	15408	NCBI Gene Model \| MGI Sequence Detail	2295	C57BL/6J	± kb
transcript	NM_008267	RefSeq \| MGI Sequence Detail	1369	ZRU/MplStud
polypeptide	P70321	UniProt \| EBI \| MGI Sequence Detail	286	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008698 homeobox protein Hox-B13

(term hierarchy)
InterPro Domains

IPR051003 Anterior-posterior axis regulatory homeobox

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR022067 Homeobox protein Hox1A3 N-terminal

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All nucleic 48

Genomic 3

cDNA 36

Primer pair 7

Other 2

Microarray probesets 4

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MGD-MRK-36306

Summaries

All 76

Developmental Gene Expression 28

Gene Ontology 8

Phenotypes 19
Earliest

J:34769 Zeltser L, et al., Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development. 1996 Aug;122(8):2475-84
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hoxb13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104432	Chr11:96085105-96085113 (+)	-33 bp
Tssr104433	Chr11:96085125-96085140 (+)	-9 bp
Tssr104434	Chr11:96085145-96085152 (+)	7 bp
Tssr104435	Chr11:96085162-96085177 (+)	28 bp
Tssr104436	Chr11:96085193-96085205 (+)	57 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24