Myo1a MGI Mouse Gene Detail - MGI:107732

Symbol

Myo1a
Name

myosin IA
Synonyms

BBM-I, brush border myosin 1, Myhl

Feature Type

protein coding gene
IDs

MGI:107732
NCBI Gene: 432516
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:127541039-127556809 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.62 cM
Mapping Data

3 experiments

SNPs within 2kb

499 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107732	protein coding gene	Chr10:127539306-127556809 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017831	protein coding gene	Chr10:131331012-131360258 (+)
A/J	MGP_AJ_G0017806	protein coding gene	Chr10:126077850-126104926 (+)
AKR/J	MGP_AKRJ_G0017769	protein coding gene	Chr10:129797437-129823700 (+)
BALB/cJ	MGP_BALBcJ_G0017770	protein coding gene	Chr10:126478569-126505070 (+)
C3H/HeJ	MGP_C3HHeJ_G0017594	protein coding gene	Chr10:129952624-129981218 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018225	protein coding gene	Chr10:135780293-135808675 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015905	protein coding gene	Chr10:120060224-120085998 (+)
CAST/EiJ	MGP_CASTEiJ_G0017154	protein coding gene	Chr10:130618868-130648564 (+)
CBA/J	MGP_CBAJ_G0017563	protein coding gene	Chr10:141262809-141292599 (+)
DBA/2J	MGP_DBA2J_G0017669	protein coding gene	Chr10:125150822-125178111 (+)
FVB/NJ	MGP_FVBNJ_G0017664	protein coding gene	Chr10:124094327-124110337 (+)
LP/J	MGP_LPJ_G0017743	protein coding gene	Chr10:131907301-131935092 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017692	protein coding gene	Chr10:143938633-143968260 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018265	protein coding gene	Chr10:129874800-129903515 (+)
PWK/PhJ	MGP_PWKPhJ_G0016939	protein coding gene	Chr10:125359356-125386435 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016731	protein coding gene	Chr10:128903160-128929163 (+)
WSB/EiJ	MGP_WSBEiJ_G0017215	protein coding gene	Chr10:130093236-130122591 (+)

Human Ortholog

MYO1A, myosin IA

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO1A, myosin IA
Synonyms

BBMI, DFNA48, MIHC, MYHL
Links

HGNC:7595

NCBI Gene ID: 4640

neXtProt AC: NX_Q9UBC5

UniProt: Q9UBC5
Chr Location

12q13.3; chr12:57028517-57051198 (-) GRCh38

MGI Vertebrate Homology

Myo1a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MYO1A
Gene Tree

Myo1a

Diseases

1 with human MYO1A associations

				Human Disease	Mouse Models
				sensorineural hearing loss IDs sensorineural hearing loss DOID:10003 DOID:11053 DOID:12112 DOID:12114 ICD10CM:H90.5 ICD9CM_2006:389.11 ICD9CM_2006:389.14 ICD9CM:389.1 ICD9CM:389.10 ICD9CM:389.14 MESH:D006319 NCI:C26739 UMLS_CUI:C0018784

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display abnormal small intestine brush border morphology, but have normal hearing.

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All GO Annotations

48
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

32
cDNA Data

15
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myo1a

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All Sequences

36
RefSeq

6
UniProt

1
CCDS

CCDS36083.1

Ensembl

ENSMUSG00000025401 (Evidence)
NCBI Gene

432516

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025401	Ensembl Gene Model \| MGI Sequence Detail	15771	C57BL/6J	± kb
transcript	ENSMUST00000079590	Ensembl \| MGI Sequence Detail	3439	Not Applicable
polypeptide	ENSMUSP00000078540	Ensembl \| MGI Sequence Detail	1043	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010855 myosin-Ia

(term hierarchy)
InterPro Domains

IPR036072 Class I myosin, motor domain

IPR010926 Class I myosin tail homology domain

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

O88329 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 20

Genomic 2

cDNA 17

Primer pair 1

Microarray probesets 2

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MGD-MRK-36308, MGI:1338019

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 14
Earliest

J:4139 Sherr EH, et al., Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. J Cell Biol. 1993 Mar;120(6):1405-16
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myo1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96244	Chr10:127539334-127539386 (+)	-1,679 bp
Tssr96245	Chr10:127539392-127539421 (+)	-1,632 bp
Tssr3395	Chr10:127541150-127541160 (+)	116 bp
Tssr96246	Chr10:127542663-127542675 (+)	1,630 bp
Tssr96247	Chr10:127542681-127542708 (+)	1,656 bp
Tssr96248	Chr10:127549902-127549913 (+)	8,869 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24