Dnah6 MGI Mouse Gene Detail - MGI:107744 - dynein, axonemal, heavy chain 6

Symbol

Dnah6
Name

dynein, axonemal, heavy chain 6
Synonyms

A730004I20Rik, Dnahc6

Feature Type

protein coding gene
IDs

MGI:107744
NCBI Gene: 330355
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:72994589-73198634 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.37 cM
Mapping Data

2 experiments

SNPs within 2kb

5833 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107744	protein coding gene	Chr6:72994586-73199327 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030886	protein coding gene	Chr6:73637647-73836246 (-)
A/J	MGP_AJ_G0030856	protein coding gene	Chr6:70721069-70915322 (-)
AKR/J	MGP_AKRJ_G0030785	protein coding gene	Chr6:72850598-73044344 (-)
BALB/cJ	MGP_BALBcJ_G0030867	protein coding gene	Chr6:70778237-70980255 (-)
C3H/HeJ	MGP_C3HHeJ_G0030845	protein coding gene	Chr6:111204300-111402114 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031325	protein coding gene	Chr6:75540622-75733843 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028514	protein coding gene	Chr6:69901551-70096909 (-)
CAST/EiJ	MGP_CASTEiJ_G0029975	protein coding gene	Chr6:72726765-72939962 (-)
CBA/J	MGP_CBAJ_G0030554	protein coding gene	Chr6:78657789-78862299 (-)
DBA/2J	MGP_DBA2J_G0030706	protein coding gene	Chr6:70136374-70328209 (-)
FVB/NJ	MGP_FVBNJ_G0030659	protein coding gene	Chr6:69537085-69730066 (-)
LP/J	MGP_LPJ_G0030785	protein coding gene	Chr6:73532835-73739288 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030694	protein coding gene	Chr6:81995564-82197504 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031351	protein coding gene	Chr6:72675770-72881095 (-)
PWK/PhJ	MGP_PWKPhJ_G0029691	protein coding gene	Chr6:69073309-69274880 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029519	protein coding gene	Chr6:71431083-71646683 (-)
WSB/EiJ	MGP_WSBEiJ_G0030057	protein coding gene	Chr6:73051486-73263682 (-)

Human Ortholog

DNAH6, dynein axonemal heavy chain 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAH6, dynein axonemal heavy chain 6
Synonyms

Dnahc6, DNHL1, HL-2, HL2
Links

HGNC:2951

NCBI Gene ID: 1768

neXtProt AC: NX_Q9C0G6

UniProt: Q9C0G6
Chr Location

2p11.2; chr2:84459572-84819589 (+) GRCh38

MGI Vertebrate Homology

Dnah6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAH6
Gene Tree

Dnah6

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

7
Spontaneous

1
Genomic Mutations

1 involving Dnah6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

223 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

5
cDNA Data

8
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnah6

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All Sequences

45
RefSeq

7
UniProt

5
CCDS

CCDS51813.1

Ensembl

ENSMUSG00000052861 (Evidence)
NCBI Gene

330355

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052861	Ensembl Gene Model \| MGI Sequence Detail	204046	C57BL/6J	± kb
transcript	ENSMUST00000204053	Ensembl \| MGI Sequence Detail	12435	Not Applicable
polypeptide	ENSMUSP00000144791	Ensembl \| MGI Sequence Detail	4144	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR026983 Dynein heavy chain

IPR041589 Dynein heavy chain 3, AAA+ lid domain

IPR043157 Dynein heavy chain, AAA1 domain, small subdomain

IPR041466 Dynein heavy chain, AAA 5 extension domain

IPR041658 Dynein heavy chain AAA lid domain

IPR042219 Dynein heavy chain AAA lid domain superfamily

IPR024317 Dynein heavy chain, AAA module D4

IPR035706 Dynein heavy chain, ATP-binding dynein motor region

IPR024743 Dynein heavy chain, coiled coil stalk

IPR041228 Dynein heavy chain, C-terminal domain

IPR043160 Dynein heavy chain, C-terminal domain, barrel region

IPR042222 Dynein heavy chain, domain 2, N-terminal

IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region

IPR013602 Dynein heavy chain, linker

IPR042228 Dynein heavy chain, linker, subdomain 3

IPR004273 Dynein heavy chain region D6 P-loop domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGD-MRK-36320, MGI:3036252

Summaries

All 32

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 10
Earliest

J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnah6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61513	Chr6:73198694-73198706 (-)	-66 bp
Tssr61512	Chr6:73198675-73198684 (-)	-46 bp
Tssr61511	Chr6:73198648-73198659 (-)	-20 bp
Tssr61510	Chr6:73198608-73198647 (-)	6 bp
Tssr61509	Chr6:73198591-73198605 (-)	36 bp
Tssr61508	Chr6:73115930-73115934 (-)	82,702 bp
Tssr61507	Chr6:73037271-73037292 (-)	161,352 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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