Dync1i2 MGI Mouse Gene Detail - MGI:107750 - dynein cytoplasmic 1 intermediate chain 2

Symbol

Dync1i2
Name

dynein cytoplasmic 1 intermediate chain 2
Synonyms

3110079H08Rik, Dncic2

Feature Type

protein coding gene
IDs

MGI:107750
NCBI Gene: 13427
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:71042050-71093647 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 42.38 cM
Mapping Data

3 experiments

SNPs within 2kb

1166 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107750	protein coding gene	Chr2:71041999-71093647 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025820	protein coding gene	Chr2:71298511-71353118 (+)
A/J	MGP_AJ_G0025797	protein coding gene	Chr2:68515773-68567990 (+)
AKR/J	MGP_AKRJ_G0025766	protein coding gene	Chr2:70385049-70439184 (+)
BALB/cJ	MGP_BALBcJ_G0025792	protein coding gene	Chr2:68706600-68758119 (+)
C3H/HeJ	MGP_C3HHeJ_G0025552	protein coding gene	Chr2:70600591-70653322 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026239	protein coding gene	Chr2:73447400-73504274 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023642	protein coding gene	Chr2:65748878-65799898 (+)
CAST/EiJ	MGP_CASTEiJ_G0025016	protein coding gene	Chr2:70786676-70843590 (+)
CBA/J	MGP_CBAJ_G0025532	protein coding gene	Chr2:76167055-76226144 (+)
DBA/2J	MGP_DBA2J_G0025663	protein coding gene	Chr2:68154557-68207930 (+)
FVB/NJ	MGP_FVBNJ_G0025626	protein coding gene	Chr2:67539143-67590888 (+)
LP/J	MGP_LPJ_G0025752	protein coding gene	Chr2:71157074-71214319 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025655	protein coding gene	Chr2:78141493-78193511 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026296	protein coding gene	Chr2:70485974-70541464 (+)
PWK/PhJ	MGP_PWKPhJ_G0024757	protein coding gene	Chr2:68016080-68070553 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024564	protein coding gene	Chr2:70681672-70734767 (+)
WSB/EiJ	MGP_WSBEiJ_G0025084	protein coding gene	Chr2:70918755-70972915 (+)

Human Ortholog

DYNC1I2, dynein cytoplasmic 1 intermediate chain 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYNC1I2, dynein cytoplasmic 1 intermediate chain 2
Synonyms

DIC74, DNCI2, IC2, NEDMIBA
Links

HGNC:2964

NCBI Gene ID: 1781

neXtProt AC: NX_Q13409

UniProt: Q13409
Chr Location

2q31.1; chr2:171687409-171750158 (+) GRCh38

MGI Vertebrate Homology

Dync1i2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DYNC1I2
Gene Tree

Dync1i2

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

62
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

56
Targeted

2
Genomic Mutations

1 involving Dync1i2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit a trend towards slight locomotor deficit.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

61
cDNA Data

206
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dync1i2

ZFIN dync1i2a, dync1i2b

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All Sequences

116
RefSeq

40
UniProt

11
CCDS

CCDS16112.1, CCDS57175.1, CCDS84536.1

Ensembl

ENSMUSG00000027012 (Evidence)
NCBI Gene

13427

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027012	Ensembl Gene Model \| MGI Sequence Detail	51598	C57BL/6J	± kb
transcript	ENSMUST00000112140	Ensembl \| MGI Sequence Detail	2573	Not Applicable
polypeptide	ENSMUSP00000107768	Ensembl \| MGI Sequence Detail	638	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000006772 cytoplasmic dynein 1 intermediate chain 2

(term hierarchy)
InterPro Domains

IPR025956 Cytoplasmic dynein 1 intermediate chain 1/2

IPR050687 Dynein Intermediate Chain

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

O88487 1 site, 1 O-linked glycan (1 site)

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All nucleic 220

cDNA 207

Primer pair 12

Other 1

Microarray probesets 3

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MGD-MRK-36326, MGI:1925763, MGI:2139394

Summaries

All 62

Developmental Gene Expression 13

Gene Ontology 9

Phenotypes 15
Earliest

J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dync1i2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18243	Chr2:71042057-71042138 (+)	48 bp
Tssr18244	Chr2:71042139-71042156 (+)	98 bp
Tssr18245	Chr2:71042172-71042183 (+)	128 bp
Tssr18246	Chr2:71042285-71042340 (+)	263 bp
Tssr18247	Chr2:71042342-71042356 (+)	299 bp
Tssr18248	Chr2:71044769-71044806 (+)	2,738 bp
Tssr18249	Chr2:71044816-71044842 (+)	2,779 bp
Tssr18250	Chr2:71091187-71091200 (+)	49,144 bp
Tssr18251	Chr2:71093215-71093270 (+)	51,193 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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