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Gfer Gene Detail
Summary
  • Symbol
    Gfer
  • Name
    growth factor, augmenter of liver regeneration
  • Synonyms
    Alr, ERV1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107757
    NCBI Gene: 11692
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24912164-24915065 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107757
 protein coding gene Chr17:24912161-24915130 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023314
 protein coding gene Chr17:23704504-23706907 (-)
A/J MGP_AJ_G0023274
 protein coding gene Chr17:23057519-23059922 (-)
AKR/J MGP_AKRJ_G0023241
 protein coding gene Chr17:23136980-23139395 (-)
BALB/cJ MGP_BALBcJ_G0023279
 protein coding gene Chr17:23243797-23246210 (-)
C3H/HeJ MGP_C3HHeJ_G0023039
 protein coding gene Chr17:23497803-23500219 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021197
 protein coding gene Chr17:20528825-20531357 (-)
CAST/EiJ MGP_CASTEiJ_G0022541
 protein coding gene Chr17:23348468-23352140 (-)
CBA/J MGP_CBAJ_G0023015
 protein coding gene Chr17:25603961-25606377 (-)
DBA/2J MGP_DBA2J_G0023144
 protein coding gene Chr17:22650667-22653070 (-)
FVB/NJ MGP_FVBNJ_G0023114
 protein coding gene Chr17:22368021-22370484 (-)
LP/J MGP_LPJ_G0023221
 protein coding gene Chr17:24010944-24013347 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023133
 protein coding gene Chr17:25301951-25304354 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023760
 protein coding gene Chr17:23419555-23421958 (-)
PWK/PhJ MGP_PWKPhJ_G0022290
 protein coding gene Chr17:21392743-21395287 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022108
 protein coding gene Chr17:21459484-21461935 (-)
WSB/EiJ MGP_WSBEiJ_G0022604
 protein coding gene Chr17:23487039-23489451 (-)



Homology
more
  • Human Ortholog
    GFER, growth factor, augmenter of liver regeneration
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GFER, growth factor, augmenter of liver regeneration
  • Synonyms
    ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, MMCHD, MPMCD
  • Links
    NCBI Gene ID: 2671
    neXtProt AC: NX_P55789
    UniProt: P55789

  • Chr Location
    16p13.3; chr16:1984193-1987749 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GFER associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before E9.5. Mice homozygous for a different knock-out allele are embryonic lethal, while heterozygotes display impaired mitochondrial biogenesis and decreased liver degeneration following partial hepatectomy or acute liver injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    70
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11692 NCBI Gene Model | MGI Sequence Detail 2902 C57BL/6J ±  kb
    transcript NM_023040 RefSeq | MGI Sequence Detail 1711 ZRU/MplStud  
    polypeptide P56213 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 4
      cDNA 70
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36333
    References
    more
    • Summaries
      All 44
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:35860 Giorda R, et al., Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. Mol Med. 1996 Jan;2(1):97-108
    • Latest
      J:332904 Zheng M, et al., Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma. Oncogene. 2023 Jan;42(4):308-321
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory