Chka MGI Mouse Gene Detail - MGI:107760

Symbol

Chka
Name

choline kinase alpha
Synonyms

Chk, ChoK, choline/ethanolamine kinase alpha, CK/EK-alpha, EtnK-alpha

Feature Type

protein coding gene
IDs

MGI:107760
NCBI Gene: 12660
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:3901773-3944369 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.57 cM
Mapping Data

5 experiments

SNPs within 2kb

922 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107760	protein coding gene	Chr19:3901585-3944369 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024630	protein coding gene	Chr19:655463-701262 (+)
A/J	MGP_AJ_G0024597	protein coding gene	Chr19:626318-669157 (+)
AKR/J	MGP_AKRJ_G0024568	protein coding gene	Chr19:630479-677508 (+)
BALB/cJ	MGP_BALBcJ_G0024595	protein coding gene	Chr19:635554-678949 (+)
C3H/HeJ	MGP_C3HHeJ_G0024364	protein coding gene	Chr19:633728-678173 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025043	protein coding gene	Chr19:646042-691572 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022472	protein coding gene	Chr19:593826-634459 (+)
CAST/EiJ	MGP_CASTEiJ_G0023836	protein coding gene	Chr19:648543-693610 (+)
CBA/J	MGP_CBAJ_G0024334	protein coding gene	Chr19:722740-767292 (+)
DBA/2J	MGP_DBA2J_G0024463	protein coding gene	Chr19:605135-647522 (+)
FVB/NJ	MGP_FVBNJ_G0024430	protein coding gene	Chr19:612801-655477 (+)
LP/J	MGP_LPJ_G0024549	protein coding gene	Chr19:649383-695639 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024460	protein coding gene	Chr19:692693-737785 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025091	protein coding gene	Chr19:636744-681552 (+)
PWK/PhJ	MGP_PWKPhJ_G0023582	protein coding gene	Chr19:627817-671088 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023388	protein coding gene	Chr19:636495-689198 (+)
WSB/EiJ	MGP_WSBEiJ_G0023899	protein coding gene	Chr19:632570-674603 (+)

Human Ortholog

CHKA, choline kinase alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHKA, choline kinase alpha
Synonyms

CHK, CK, CKI, EK, NEDMIMS
Links

HGNC:1937

NCBI Gene ID: 1119

neXtProt AC: NX_P35790

UniProt: P35790
Chr Location

11q13.2; chr11:68052859-68121444 (-) GRCh38

MGI Vertebrate Homology

Chka stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHKA
Gene Tree

Chka

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Gene trapped

12
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality between E3.5 and E7.5.

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All GO Annotations

42
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

844
Tissues

124
cDNA Data

11
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chka

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All Sequences

110
RefSeq

33
UniProt

8
CCDS

CCDS29400.1, CCDS70913.1

Ensembl

ENSMUSG00000024843 (Evidence)
NCBI Gene

12660

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024843	Ensembl Gene Model \| MGI Sequence Detail	42597	C57BL/6J	± kb
transcript	ENSMUST00000025760	Ensembl \| MGI Sequence Detail	2319	Not Applicable
polypeptide	ENSMUSP00000025760	Ensembl \| MGI Sequence Detail	453	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005427 choline kinase alpha

(term hierarchy)
EC

2.7.1.32, 2.7.1.82
InterPro Domains

IPR011009 Protein kinase-like domain superfamily

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All nucleic 16

cDNA 13

Primer pair 2

Other 1

Microarray probesets 6

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MGD-MRK-36336

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 13
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Chka:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154194	Chr19:3901800-3901811 (+)	33 bp
Tssr154195	Chr19:3901823-3901840 (+)	59 bp
Tssr154196	Chr19:3901855-3901860 (+)	85 bp
Tssr154197	Chr19:3901927-3901934 (+)	158 bp
Tssr154198	Chr19:3901939-3901948 (+)	171 bp
Tssr154199	Chr19:3901957-3901962 (+)	187 bp
Tssr154200	Chr19:3901972-3901981 (+)	204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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