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Apbb1 Gene Detail
Summary
  • Symbol
    Apbb1
  • Name
    amyloid beta precursor protein binding family B member 1
  • Synonyms
    Fe65, Rir
  • Feature Type
    protein coding gene
  • IDs
    MGI:107765
    NCBI Gene: 11785
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105207690-105230860 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.90 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    548 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107765
 protein coding gene Chr7:105207690-105231151 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032755
 protein coding gene Chr7:108816250-108840903 (-)
A/J MGP_AJ_G0032735
 protein coding gene Chr7:105966586-105990286 (-)
AKR/J MGP_AKRJ_G0032668
 protein coding gene Chr7:108739639-108764735 (-)
BALB/cJ MGP_BALBcJ_G0032741
 protein coding gene Chr7:105682468-105705961 (-)
C3H/HeJ MGP_C3HHeJ_G0032450
 protein coding gene Chr7:108839492-108866309 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033246
 protein coding gene Chr7:113174420-113198219 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030230
 protein coding gene Chr7:107946606-107969347 (-)
CAST/EiJ MGP_CASTEiJ_G0031780
 protein coding gene Chr7:100669656-100695478 (-)
CBA/J MGP_CBAJ_G0032424
 protein coding gene Chr7:116925687-116951156 (-)
DBA/2J MGP_DBA2J_G0032577
 protein coding gene Chr7:104237506-104260856 (-)
FVB/NJ MGP_FVBNJ_G0032530
 protein coding gene Chr7:104042625-104067284 (-)
LP/J MGP_LPJ_G0032668
 protein coding gene Chr7:110212782-110238275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032562
 protein coding gene Chr7:118528038-118553503 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033267
 protein coding gene Chr7:107797142-107822652 (-)
PWK/PhJ MGP_PWKPhJ_G0031493
 protein coding gene Chr7:97174779-97199383 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031342
 protein coding gene Chr7:94915864-94940349 (-)
WSB/EiJ MGP_WSBEiJ_G0031897
 protein coding gene Chr7:108440774-108468045 (-)



Homology
more
  • Human Ortholog
    APBB1, amyloid beta precursor protein binding family B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APBB1, amyloid beta precursor protein binding family B member 1
  • Synonyms
    FE65, MGC:9072, RIR
  • Links
    NCBI Gene ID: 322
    neXtProt AC: NX_O00213
    UniProt: O00213

  • Chr Location
    11p15.4; chr11:6395124-6419453 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human APBB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are hypersensitive to ionizing radiation while mouse embryonic fibroblasts are hypersensitive to DNA damaging agents. Homozygotes for a second null allele display impaired performance in learning and memory tasks, with a striking deficit in reversal spatial learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    959
  • Tissues
    126
  • cDNA Data
    18
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037032 Ensembl Gene Model | MGI Sequence Detail 23171 C57BL/6J ±  kb
transcript ENSMUST00000191601 Ensembl | MGI Sequence Detail 2690 Not Applicable  
polypeptide ENSMUSP00000140116 Ensembl | MGI Sequence Detail 710 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 18
    Primer pair 1
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36342
References
more
  • Summaries
    All 80
    Developmental Gene Expression 9
    Gene Ontology 21
    Phenotypes 27
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory