Akr7a5 MGI Mouse Gene Detail - MGI:107796 - aldo-keto reductase family 7, member A5

Symbol

Akr7a5
Name

aldo-keto reductase family 7, member A5
Synonyms

0610025K21Rik, Afar

Feature Type

protein coding gene
IDs

MGI:107796
NCBI Gene: 110198
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:139038055-139045737 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.64 cM, cytoband D3
Mapping Data

5 experiments

SNPs within 2kb

368 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107796	protein coding gene	Chr4:139038005-139046097 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029015	protein coding gene	Chr4:142136923-142145696 (+)
A/J	MGP_AJ_G0028974	protein coding gene	Chr4:136026139-136033646 (+)
AKR/J	MGP_AKRJ_G0028926	protein coding gene	Chr4:139922733-139930395 (+)
BALB/cJ	MGP_BALBcJ_G0028998	protein coding gene	Chr4:136702974-136710916 (+)
C3H/HeJ	MGP_C3HHeJ_G0028712	protein coding gene	Chr4:140302315-140310108 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029439	protein coding gene	Chr4:147167249-147180006 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026710	protein coding gene	Chr4:128999707-129007358 (+)
CAST/EiJ	MGP_CASTEiJ_G0028144	protein coding gene	Chr4:138481144-138490405 (+)
CBA/J	MGP_CBAJ_G0028676	protein coding gene	Chr4:151418174-151426441 (+)
DBA/2J	MGP_DBA2J_G0028826	protein coding gene	Chr4:136425399-136433064 (+)
FVB/NJ	MGP_FVBNJ_G0028793	protein coding gene	Chr4:135445789-135453792 (+)
LP/J	MGP_LPJ_G0028925	protein coding gene	Chr4:142211083-142218762 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028819	protein coding gene	Chr4:155319180-155326857 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029477	protein coding gene	Chr4:140450158-140459939 (+)
PWK/PhJ	MGP_PWKPhJ_G0027865	protein coding gene	Chr4:133273532-133281652 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027690	protein coding gene	Chr4:136224030-136233387 (+)
WSB/EiJ	MGP_WSBEiJ_G0028222	protein coding gene	Chr4:140702984-140709506 (+)

Human Ortholog

AKR7A2, aldo-keto reductase family 7 member A2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKR7A2, aldo-keto reductase family 7 member A2
Synonyms

AFAR, AFAR1, AFB1-AR1, AKR7
Links

HGNC:389

NCBI Gene ID: 8574

neXtProt AC: NX_O43488

UniProt: O43488
Chr Location

1p36.13; chr1:19302708-19312146 (-) GRCh38

Human Ortholog

AKR7A3, aldo-keto reductase family 7 member A3
Synonyms

AFAR2
Links

HGNC:390

NCBI Gene ID: 22977

neXtProt AC: NX_O95154

UniProt: O95154
Chr Location

1p36.13; chr1:19274229-19288770 (-) GRCh38

Human Ortholog

AKR7L, aldo-keto reductase family 7 like (gene/pseudogene)
Synonyms

AFAR3, AFB1-AR 3, AFB1-AR3, AKR7A4
Links

HGNC:24056

NCBI Gene ID: 246181

neXtProt AC: NX_Q8NHP1

UniProt: Q8NHP1
Chr Location

1p35-p36.1; chr1:19265982-19274194 (-) GRCh38

MGI Vertebrate Homology

Akr7a5 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AKR7A2, AKR7A3, AKR7L
Gene Tree

Akr7a5

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

6
Genomic Mutations

3 involving Akr7a5
Incidental Mutations

CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

95
cDNA Data

89
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

3
UniProt

1
CCDS

CCDS18844.1

Ensembl

ENSMUSG00000028743 (Evidence)
NCBI Gene

110198

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028743	Ensembl Gene Model \| MGI Sequence Detail	7683	C57BL/6J	± kb
transcript	ENSMUST00000073787	Ensembl \| MGI Sequence Detail	1288	Not Applicable
polypeptide	ENSMUSP00000073459	Ensembl \| MGI Sequence Detail	367	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003908 aflatoxin B1 aldehyde reductase member 2

(term hierarchy)
PDB

2C91
EC

1.1.1.n11
InterPro Domains

IPR050523 Aldo/Keto Reductase Detoxification and Biosynthesis

IPR023210 NADP-dependent oxidoreductase domain

IPR036812 NADP-dependent oxidoreductase domain superfamily
GlyGen

Q8CG76 1 site, 1 O-linked glycan (1 site)

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All nucleic 90

cDNA 89

Primer pair 1

Microarray probesets 3

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MGD-MRK-36373, MGI:1913326

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 11
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:358012 Shi H, et al., AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice. J Cell Mol Med. 2024 Oct;28(19):e70129

TSS for Akr7a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39935	Chr4:139038043-139038104 (+)	19 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24