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Tubb3 Gene Detail
Summary
  • Symbol
    Tubb3
  • Name
    tubulin, beta 3 class III
  • Synonyms
    3200002H15Rik, betaIII-tubulin, Tuj1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107813
    NCBI Gene: 22152
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124138292-124148754 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107813
 protein coding gene Chr8:124138163-124148754 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034255
 protein coding gene Chr8:127024072-127036706 (+)
A/J MGP_AJ_G0034235
 protein coding gene Chr8:121767766-121778740 (+)
AKR/J MGP_AKRJ_G0034162
 protein coding gene Chr8:125304801-125317294 (+)
BALB/cJ MGP_BALBcJ_G0034228
 protein coding gene Chr8:121970126-121980718 (+)
C3H/HeJ MGP_C3HHeJ_G0033939
 protein coding gene Chr8:126004631-126016005 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034748
 protein coding gene Chr8:131275472-131286601 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031690
 protein coding gene Chr8:114584535-114595442 (+)
CAST/EiJ MGP_CASTEiJ_G0033267
 protein coding gene Chr8:126103639-126116256 (+)
CBA/J MGP_CBAJ_G0033912
 protein coding gene Chr8:136093710-136104463 (+)
DBA/2J MGP_DBA2J_G0034068
 protein coding gene Chr8:120934331-120945327 (+)
FVB/NJ MGP_FVBNJ_G0034012
 protein coding gene Chr8:120107214-120118881 (+)
LP/J MGP_LPJ_G0034158
 protein coding gene Chr8:127169661-127181773 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034059
 protein coding gene Chr8:138222299-138235399 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034767
 protein coding gene Chr8:125509962-125522193 (+)
PWK/PhJ MGP_PWKPhJ_G0032968
 protein coding gene Chr8:120769981-120781220 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032808
 protein coding gene Chr8:124230131-124240557 (+)
WSB/EiJ MGP_WSBEiJ_G0033383
 protein coding gene Chr8:126247498-126267149 (+)



Homology
more
  • Human Ortholog
    TUBB3, tubulin beta 3 class III
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBB3, tubulin beta 3 class III
  • Synonyms
    beta-4, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4
  • Links
    NCBI Gene ID: 10381
    neXtProt AC: NX_Q13509
    UniProt: Q13509

  • Chr Location
    16q24.3; chr16:89921392-89938761 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tubb3 mouse models; 2 with human TUBB3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit neonatal lethality associated with respiratory distress, abnormal corpus callosum morphology, abnormal cranial nerves, and defective axon guidance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3461
  • Tissues
    666
  • cDNA Data
    133
  • Literature Summary
    1772
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22152 NCBI Gene Model | MGI Sequence Detail 10463 C57BL/6J ±  kb
    transcript NM_023279 RefSeq | MGI Sequence Detail 1757 C57BL/6  
    polypeptide Q9ERD7 UniProt | EBI | MGI Sequence Detail 450 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      Genomic 1
      cDNA 133
      Primer pair 13
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36390, MGI:1914177
    References
    more
    • Summaries
      All 1844
      Developmental Gene Expression 1772
      Diseases 1
      Gene Ontology 28
      Phenotypes 10
    • Earliest
      J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory