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Adam8 Gene Detail
Summary
  • Symbol
    Adam8
  • Name
    a disintegrin and metallopeptidase domain 8
  • Synonyms
    CD156, CD156a, E430039A18Rik, MS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107825
    NCBI Gene: 11501
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:139558845-139572475 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 84.96 cM, cytoband F3-F5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107825
 protein coding gene Chr7:139558845-139573016 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033157
 protein coding gene Chr7:145054639-145070946 (-)
A/J MGP_AJ_G0033139
 protein coding gene Chr7:140939631-140956625 (-)
AKR/J MGP_AKRJ_G0033071
 protein coding gene Chr7:144774607-144790946 (-)
BALB/cJ MGP_BALBcJ_G0033140
 protein coding gene Chr7:140675879-140689510 (-)
C3H/HeJ MGP_C3HHeJ_G0032854
 protein coding gene Chr7:144569311-144582947 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033651
 protein coding gene Chr7:150397618-150413053 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030624
 protein coding gene Chr7:142062640-142076121 (-)
CAST/EiJ MGP_CASTEiJ_G0032184
 protein coding gene Chr7:136874030-136887771 (-)
CBA/J MGP_CBAJ_G0032827
 protein coding gene Chr7:155468138-155481773 (-)
DBA/2J MGP_DBA2J_G0032979
 protein coding gene Chr7:138889385-138903033 (-)
FVB/NJ MGP_FVBNJ_G0032932
 protein coding gene Chr7:138777830-138792734 (-)
LP/J MGP_LPJ_G0033073
 protein coding gene Chr7:146610626-146625737 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032964
 protein coding gene Chr7:156131704-156145705 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033671
 protein coding gene Chr7:143770702-143784321 (-)
PWK/PhJ MGP_PWKPhJ_G0031890
 protein coding gene Chr7:132084633-132098565 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031735
 protein coding gene Chr7:130608560-130622376 (-)
WSB/EiJ MGP_WSBEiJ_G0032295
 protein coding gene Chr7:144671906-144685559 (-)



Homology
more
  • Human Ortholog
    ADAM8, ADAM metallopeptidase domain 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM8, ADAM metallopeptidase domain 8
  • Synonyms
    CD156, CD156a, MS2
  • Links
    NCBI Gene ID: 101
    neXtProt AC: NX_P78325
    UniProt: P78325

  • Chr Location
    10q26.3; chr10:133262420-133276868 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice do not exhibit any morphological or pathological abnormalities. Mice homozygous for a different knock-out allele exhibit reduced osteoclast differentiation and calvarial fibrosis in response to TNF-alpha treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    42
  • cDNA Data
    54
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025473 Ensembl Gene Model | MGI Sequence Detail 13631 C57BL/6J ±  kb
    transcript ENSMUST00000106069 Ensembl | MGI Sequence Detail 3117 Not Applicable  
    polypeptide ENSMUSP00000101684 Ensembl | MGI Sequence Detail 826 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 2
      cDNA 55
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36402, MGI:2443633
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 8
      Gene Ontology 21
      Phenotypes 33
    • Earliest
      J:11115 Yoshida S, et al., Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage. Int Immunol. 1990;2(6):585-91
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory